Domestic Animal Endocrinology
Volume 31, Issue 2 , Pages 197-210 , August 2006

Leptin secretion in horses: Effects of dexamethasone, gender, and testosterone

  • J.A. Cartmill

      Affiliations

    • Present address: Texas A&M University Agricultural Research Station, Beeville, TX 78102-9410, USA.
    • ,
  • D.L. Thompson Jr.

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +1 225 578 3445; fax: +1 225 578 3279.
    • ,
  • R.P. Del Vecchio

      Affiliations

    • Present address: Agriculture Department, University of Minnesota-Crookston, Crookston, MN, USA.
    • ,
  • W.A. Storer
    • ,
  • J.C. Crowley

Received 8 March 2005 ,Revised 23 October 2005 ,Accepted 24 October 2005.

References 

  1. Gentry LR, Thompson DL, Gentry GT, Davis KA, Godke RA. High versus low body condition in mares: interactions with responses to somatotropin, GnRH analog, and dexamethasone. J Anim Sci. 2002;80:3277–3285
  2. Cartmill JA, Thompson DL, Gentry LR, Pruett HE, Johnson CA. Effects of dexamethasone, glucose infusion, adrenocorticotropin, and propylthiouracil on plasma leptin concentrations in horses. Domest Anim Endocrinol. 2003;24:1–14
  3. Cartmill JA, Thompson DL, Storer WA, Gentry LR, Huff NK. Endocrine responses in mares and geldings with high body condition scores grouped by high versus low resting leptin concentrations. J Anim Sci. 2003;81:2311–2321
  4. Tanaka M, Nakaya S, Kumai T, Watanabe M, Tateishi T, Shimizu H, et al. Effects of estrogen on serum leptin levels and leptin mRNA expression in adipose tissure in rats. Horm Res. 2001;56:98–104
  5. Simon D, Charles M, Lahlou N, Nahoul K, Oppert J, Gouault-Heilmann M, et al. Androgen therapy improves insulin sensitivity and decreases leptin level in healthy adult men with low plasma total testosterone. Diabetes Care. 2001;24:2149–2151
  6. Kauter K, Ball M, Kearney P, Tellam R, McFarlane JR. Adrenaline, insulin and glucagons do not have acute effects on plasma leptin levels in sheep: development and characterization of an ovine leptin ELISA. J Endocrinol. 2000;166:127–135
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  10. Saad MF, Damani S, Gingerich RL, Riad-Gabriel MG, Khan A, Boyadjian R, et al. Sexual dimorphism in plasm leptin concentation. J Clin Endocrinol Metab. 1997;82:579–584
  11. Landt M, Gingerich RL, Havel PJ, Mueller WM, Schoner B, Hale JE, et al. Radioimmunoassay of rat leptin: sexual dimorphism reversed from humans. Clin Chem. 1998;44:565–570
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  13. Smith JT, Waddell BJ. Developmental changes in plasma leptin and hypothalamic leptin receptor expression in the rat: peripubertal changes and the emergence of sex differences. J Endocrinol. 2003;176:313–319
  14. Pinilla L, Seoane L, Gonzalez L, Carro E, Aguilar E, Casanueva FF, et al. Regulation of serum leptin levels by gonadal function in rats. Eur J Endocrinol. 1999;140:468–473
  15. Bagnasco M, Kalra PS, Kalra SP. Plasma leptin levels are pulsatile in adult rats: effects of gonadectomy. Neuroendocrinology. 2002;75:257–263
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  17. Henneke DR, Potter GD, Kreider JL, Yeates BF. Relationship between condition score, physical measurements and body fat percentage in mares. Equine Vet J. 1983;15:371–376
  18. Gentry LR, Thompson DL, Gentry GT, Del Vecchio RP, Davis KA, Del Vecchio PM. The relationship between body condition score and ultrasonic fat measurements in mares of high versus low body condition. J Equine Vet Sci. 2004;24:198–203
  19. Thompson DL, Pickett BW, Squires EL, Nett TM. Sexual behavior, seminal pH, and accessory sex gland weights in geldings administered testosterone and (or) estradiol-17 beta. J Anim Sci. 1980;51:1358–1366
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  21. Sticker LS, Thompson DL, Fernandez JM, Bunting LD, DePew CL. Dietary protein and (or) energy restriction in mares: plasma growth hormone, IGF-1, cortisol, and thyroid hormone responses to feeding, glucose, and epinephrine. J Anim Sci. 1995;73:1424–1432
  22. McManus CJ, Fitzgerald BP. Effects of a single day of feed restriction on changes in serum leptin, gonadotropins, prolactin and metabolites in aged and young mares. Domest Anim Endocrinol. 2000;19:1–13
  23. Gill JL, Hafs HD. Analysis of repeated measurements of animals. J Anim Sci. 1971;33:331–336
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  26. Smith LA, Thompson DL, French DD, Leise BS. Effects of recombinant equine somatotropin on wound healing, carbohydrate and lipid metabolism, and endogenous somatotropin responses to secretagogues in geldings. J Anim Sci. 1999;77:1815–1822
  27. Buonomo FC, Ruffin DS, Brendemeuhl JP, Veenhuizen JJ, Sartin JL. The effects of bovine somatotropin (bST) and porcine somatotropin (pST) on growth factor and metabolic variables in horses. J Anim Sci. 1996;74:886–894
  28. Houseknecht KL, Portocarrero CP, Ji S, Lemenager R, Spurlock ME. Growth hormone regulates leptin gene expression in bovine adipose tissue: correlation with adipose IGF-1 expresssion. J Endocrinol. 2000;164:51–57
  29. Bereket A, Lang CH, Wilson TA. Alterations in the growth hormone-insulin-like growth factor axis in insulin dependent diabetes mellitus. Horm Metab Res. 1999;31:172–181
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  31. Cartmill JA, Thompson DL, Storer WA, Crowley JC, Huff NK, Waller CA. Effect of dexamethasone, feeding time, and insulin infusion on leptin concentrations in stallions. J Anim Sci. 2005;83:1875–1881
  32. Piccioni G, Bertolucci C, Foa A, Caola G. Influence of fasting and exercise on the daily rhythm of serum leptin in the horse. Chronobiol Int. 2004;21:405–417
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  34. Storer WA, Thompson DL Jr., Waller CA, Cartmill JA. Endocrine profiles in hyperleptinemic and normal mares in response to common feeding practices. 19th Symposium Proceedings. Savoy: Equine Science Society; 2005. p. 144.
  35. Sojka JE, Johnson MA, Bottoms GD. The effect of starting time on dexamethasone suppression test results in horses. Domest Anim Endocrinol. 1993;10:1–5
  36. Eiler H, Oliver JW, Andrews FM, Fecteau KA, Green EM, McCracken M. Results of a combined dexamethasone suppression/thyrotropin-releasing hormone stimulation test in healthy horses and horses suspected to have a pars intermedia pituitary adenoma. J Am Vet Med Assoc. 1997;211:79–81

☆ Approved for publication by the Director of the Louisiana Agricultural Experiment Station as manuscript no. 05-18-0154.

PII: S0739-7240(05)00218-3

doi: 10.1016/j.domaniend.2005.10.006

Domestic Animal Endocrinology
Volume 31, Issue 2 , Pages 197-210 , August 2006

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