Domestic Animal Endocrinology
Volume 37, Issue 4 , Pages 196-205 , November 2009

Dynamics of GHRH in third-ventricle cerebrospinal fluid of cattle: Relationship with serum concentrations of GH and responses to appetite-regulating peptides

  • M.G. Thomas

      Affiliations

    • Department of Animal and Range Sciences, New Mexico State University, Las Cruces, NM 88003, USA
    • Corresponding Author InformationCorresponding author. Department of Animal and Range Sciences, MSC 3I, Knox Hall 328, 2980 South Espina St, New Mexico State University, Las Cruces, NM 88003, USA. Tel.: +1 575 646 3427; fax: +1 575 646 3488.
    • ,
  • M. Amstalden

      Affiliations

    • Department of Animal Science, Texas A&M University, College Station, TX 77843-2471, USA
    • ,
  • D.M. Hallford

      Affiliations

    • Department of Animal and Range Sciences, New Mexico State University, Las Cruces, NM 88003, USA
    • ,
  • G.A. Silver

      Affiliations

    • Department of Animal and Range Sciences, New Mexico State University, Las Cruces, NM 88003, USA
    • ,
  • M.D. Garcia

      Affiliations

    • Department of Animal and Range Sciences, New Mexico State University, Las Cruces, NM 88003, USA
    • Present address: Department of Animal Sciences, 105 J.B. Francioni Hall, Louisiana State University, Baton Rouge, LA 70803.
    • ,
  • D.H. Keisler

      Affiliations

    • Division of Animal Sciences, University of Missouri, Columbia, MO 65211, USA
    • ,
  • G.L. Williams

      Affiliations

    • Texas AgriLife Research Station, Beeville, TX 78102, USA

Received 11 February 2009 ,Revised 27 May 2009 ,Accepted 28 May 2009.

References 

  1. Etherton TD. Somatotropic function: The somatomedin hypothesis revisited. J Anim Sci. 2004;82(E. Suppl.):E239–E244
  2. Chagas LM, Bass JJ, Blanche D, et al. Invited review: New perspectives on the roles of nutrition and metabolic priorities in the subfertility of high-producing dairy cows. J Dairy Sci. 2007;90:4022–4032
  3. Leshin LS, Barb CR, Kiser TE, Rampacek GB, Kraeling RB. Growth hormone–releasing hormone and somatostatin neurons within the porcine and bovine hypothalamus. Neuroendocrinology. 1994;59:251–264
  4. Carretero J, Burks D, Rubio M, et al. Immunocytochemical evidence for growth hormone–releasing hormone in the tanycytes of the median eminence of the rat. Folia Morphol (Warsz). 2002;61:209–216
  5. Moore KL, Armstrong JD, Harvey RW, Campbell RM, Heimer EP. Effect of active immunization against growth hormone–releasing factor on concentrations of somatotropin and insulin-like growth factor I in lactating beef cows. Domest Anim Endocrinol. 1992;9:125–139
  6. Harvey RW, Armstrong JD, Heimer EP, Campbell RM. Feedlot performance, carcass characteristics, hormones, and metabolites in steers actively immunized against growth hormone–releasing factor. J Anim Sci. 1993;71:2853–2859
  7. Kirby CJ, Armstrong JD, Huff BG, et al. Changes in serum somatotropin, somatotropin mRNA, and serum and follicular insulin-like growth factor-I in response to feed restriction in cows actively immunized against growth hormone–releasing factor. J Anim Sci. 1993;71:3033–3042
  8. Guillemin R. Hypothalamic hormones a.k.a. hypothalamic releasing factors. J Endocrinol. 2005;184:11–28
  9. MacGregor DJ, Leng G. Modeling the hypothalamic control of growth hormone secretion. J Neuroendocrinol. 2005;12:788–803
  10. Anubhuti AS. Role of neuropeptides in appetite regulation and obesity—a review. Neuropeptides. 2006;40:375–401
  11. Magnan E, Cataldi M, Guillaume V, et al. Neostigmine stimulates growth hormone–releasing hormone release into hypophysial portal blood of conscious sheep. Endocrinology. 1993;132:1247–1251
  12. Cataldi M, Magnan E, Guillaume V, et al. Relationship between hypohyseal portal GHRH and somatostatin and peripheral GH levels in conscious sheep. J Endocrinol Invest. 1994;17:717–722
  13. Fletcher TP, Thomas GB, Clarke IJ. Growth hormone–releasing hormone and somatostatin concentrations in the hypophysial portal blood of conscious sheep during the infusión of growth hormone–releasing peptide-6. Domest Anim Endocrinol. 2004;13:251–258
  14. Skinner DC, Caraty A, Malpaux B, Evans NP. Simultaneous measurement of gonadotropin–releasing hormone in the third ventricular cerebrospinal fluid and hypophyseal portal blood of the ewe. Endocrinology. 1997;138:4699–4704
  15. Gazal OS, Leshin LS, Stanko RL, et al. Gonadotropin-releasing hormone secretion in third ventricle cerebrospinal fluid of cattle: correspondence with the tonic and surge release of luteinizing hormone and its tonic inhibition by suckling and neuropeptide Y. Biol Reprod. 1998;59:676–683
  16. Kashio Y, Chihara K, Kaji H, et al. Presence of growth hormone-releasing factor-like immunoreactivity in human cerebrospinal fluid. J Clin Endocrinol Metab. 1985;60:396–398
  17. Brunani A, Invitti C, Dubini A, et al. Cerebrospinal fluid and plasma concentrations of SRIH, beta-endorphin, CRH, NPY and GHRH in obese and normal weight subjects. Int J Obes. 1995;19:17–21
  18. Gomez JM, Aguilar M, Navarro MA, Ortola J, Soler J. GH response to GH-releasing hormone (GHRH) in Alzheimer and vascular dementia. Relation with somatostatin cerebrospinal levels. Annal d’Endocrinol. 1996;57:107–110
  19. Zieba DA, Amstalden M, Morton S, et al. Effects of leptin on basal and GHRH-stimulated GH secretion from the bovine adenohypophysis are dependent upon nutritional status. J Endocrinol. 2003;178:83–89
  20. Thomas MG, Gazal OS, Williams GL, Stanko RL, Keisler DH. Injection of Neuropeptide Y in the third cerebroventricle differentially influences pituitary secretion of luteinizing hormone and growth hormone in ovariectomized cows. Domest Anim Endocrinol. 1999;16:159–169
  21. Garcia MR, Amstalden M, Keisler DH, Raver N, Gertler A, Williams GL. Leptin attenuates the acute effects of centrally administered neuropeptide Y on somatotropin but not gonadotropin secretion in ovariectomized cows. Domest Anim Endocrinol. 2004;26:189–200
  22. Cutshaw JL, Hunter JF, Williams GL. Effects of transcutaneous thermal and electrical stimulation of the teat on pituitary luteinzing hormone, prolactin and oxytocin secretion in ovariectomized, estradiol-treated beef cows following acute weaning. Theriogenology. 1992;37:915–934
  23. Morrison CD, Daniel JA, Holmberg BJ, et al. Central infusion of leptin into well-fed and undernourished ewe lambs: effects on feed intake and serum concentrations of growth hormone and luteinizing hormone. J Endocrinol. 2001;168:317–324
  24. Amstalden M, Garcia MR, Stanko RL, et al. Central infusion of recombinant ovine leptin normalizes plasma insulin and stimulates a novel hypersecretion of luteinizing hormone after a short-term fasting in mature beef cows. Biol Reprod. 2002;66:1555–1561
  25. Hoefler WC, Hallford DM. Influence of suckling status and type of birth on serum hormone profiles and return to estrus in early-postpartum, spring-lambing ewes. Theriogenology. 1987;27:887–895
  26. Reecy JM, Williams JE, Kerley MS, MacDonald RS, Thornton WH, Wallace LM. Abomasal casein infusion enhances the mitogenic activity of serum from protein-restricted steers. J Nutr. 1994;124:67–77
  27. Johnson ML. Pulse_XP. Available at: http://mljohnson.pharm.virginia.edu/Hormone_Overview_0803.pdf. Accessed November 1, 2007.
  28. Trenkle A. Growth hormone secretion rates in cattle. J Anim Sci. 1970;32:115–118
  29. Soszynski P, Jeske W, Rogozinski W, Zgliczynski S. Radioimmunological determination of exogenous corticotrophin-releasing hormone (CRH) and growth hormone releasing hormone (GHRH): plasma half-life of CRH and GHRH. Endokrynol Pol. 1989;40:227–233
  30. Smith RG. Development of growth hormone secretagogues. Endocr Rev. 2005;26:346–360
  31. Zieba DA, Amstalden M, Morton S, Maciel MN, Keisler DH, Williams GL. Regulatory roles of leptin at the hypothalamic-hypophyseal axis before and after sexual maturation in cattle. Biol Reprod. 2004;71:804–812
  32. Clarke IJ. Two decades of measuring GnRH secretion. Reprod Suppl. 2002;59:1–13
  33. Smith JT, Rao A, Pereira A, Caraty A, Millar RP, Clarke IJ. Kisspeptin is present in ovine hypophysial portal blood but does not increase during the preovulatory luteinizing hormone surge: evidence that gonadotropes are not direct targets of kisspeptin in vivo. Endocrinology. 2008;149:1951–1959
  34. Irvine CH, Alexander SL. A novel technique for measuring hypothalamic and pituitary hormone secretion rates from collection of pituitary venous effluent in the normal horse. J Endocrinol. 1987;133:183–192
  35. Irvine CH, Alexander SL. Patterns of secretion of GnRH, LH and FSH during the postovulatory period in mares: mechanisms prolonging the LH surge. J Reprod Fertil. 1997;109:263–271
  36. Mogi K, Yonezawa T, Chen DS, et al. Relationship between the growth hormone pulses in the peripheral circulation and GH-releasing hormone and somatostatin profiles in the cerebrospinal fluid of goats. J Vet Med Sci. 2004;66:1071–1078
  37. Caraty A, Skinner DC. Gonadotropin-releasing hormone in third ventricular cerebrospinal fluid: endogenous distribution and exogenous uptake. Endocrinology. 2008;149:5227–5234
  38. Kasuya E, Sakumoto R, Saito T, et al. A novel sterotaxic approach to the hypothalamus for the use of push-pull perfusion cannula in Holstein calves. J Neurosci Methods. 2005;141:115–124
  39. McMahon CD, Radcliff RP, Lookingland KJ, Tucker HA. Neuroregulation of growth hormone secretion in domestic animals. Domest Anim Endocriol. 2001;20:65–87
  40. Wuttke W, Jarry H, Feleder C, et al. The neurochemistry of the GnRH pulse generator. Acta Neurobiol Exp. 1996;56:707–713
  41. Hill JW, Elmquist JK, Elias CF. Hypothalamic pathways linking energy balance and reproduction. Am J Physiol Endocrinol Metab. 2008;294:E827–832
  42. Ojeda SR, Lomniczi A, Mastronardi C, et al. Minireview: the neuroendocrine regulation of puberty: is the time ripe for a systems biology approach. Endocrinology. 2006;147:1166–1174
  43. Sultan MM, Schulz H, Richard H, et al. A gobal view of gene activity and alternative splicing by deep sequencing of the human transcriptome. Science. 2008;321:956–960
  44. Roth CL, Mastronardi C, Lomniczi A, et al. Expression of a tumor-related gene network increase in the mammalian hypothalamus at the time of female puberty. Endocrinology. 2007;148:5147–5156
  45. Mudge J, Miller NA, Khrebtukova I, et al. Genomic convergence analysis of schizophrenia: mRNA sequence reveals altered synaptic vesicular transport in post-mortem cerebellum. PLoS One. 2008;3:e3625
  46. Adam CL, Archer ZA, Findlay PA, Thomas L, Marie M. Hypothalamic gene expression in sheep for cocaine- and amphetamine-regulated transcript, pro-opiomelanocortin, neuropeptide Y, agouti-related peptide and leptin receptor and responses to negative energy balance. Neuroendocrinology. 2002;75:250–256
  47. Ryan DP, Spoon RA, Griffith MK, Williams GL. Ovarian follicular recruitment, granulose cell steroidogenic potential and growth hormone/insulin-like growth factor-I relationships in suckled beef cows consuming high lipid diets: effects of graded differences in body condition maintained during the puerperium. Domest Anim Endocrionol. 1994;11:161–174
  48. Douyon L, Schteingart DE. Effect of obesity and starvation on thyroid hormone, growth hormone, and cortisol secretion. Endocrinol Metab Clin North Am. 2002;31:173–189
  49. Narro LA, Thomas MG, Silver GA, Rozeboom KJ, Keisler DH. Body composition, leptin, and the leptin receptor and their relationship to the growth hormone (GH) axis in growing wethers treated with zeranol. Domest Anim Endocrinol. 2003;24:243–255
  50. Luque RM, Park S, Kineman RD. Severity of the catabolic condition differentially modulates hypothalamic expression of growth hormone-releasing hormone in the fasted mouse: potential role of neuropeptide Y and corticotrophin-releasing hormone. Endocrinology. 2007;148:300–309
  51. Denniston DJ, Thomas MG, Kane KK, et al. Effect of neuropeptide Y on GnRH-induced LH release from bovine anterior pituitary cell cultures derived from heifers in a follicular, luteal, or ovariectomized state. Anim Reprod Sci. 2003;78:25–31
  52. Stepanyan Z, Kocharyan A, Behrens M, Koebnick C, Pyrski C, Meyerhof W. Somatostatin, a negative-regulator of central leptin action in the rat hypothalamus. J Neurochem. 2007;100:468–478
  53. Tung YC, Ma M, Piper S, Coll A, O’Rahilly S, Yeo GS. Novel leptin-regulated genes revealed by transcriptional profiling of the hypothalamic paraventricular nucleus. J Neurosci. 2008;28:12419–12426

PII: S0739-7240(09)00069-1

doi: 10.1016/j.domaniend.2009.05.006

Domestic Animal Endocrinology
Volume 37, Issue 4 , Pages 196-205 , November 2009

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