Domestic Animal Endocrinology
Volume 38, Issue 1 , Pages 46-56 , January 2010

Altered “set-point” of the hypothalamus determines effects of cortisol on food intake, adiposity, and metabolic substrates in sheep

  • B.A. Henry

      Affiliations

    • Department of Physiology, Building 13 F, Wellington Road, Monash University, VIC 3800, Australia
    • Corresponding Author InformationCorresponding author. Tel.: +61 3 99052500; fax: +61 3 99052566.
    • ,
  • D. Blache

      Affiliations

    • School of Animal Biology, University of Western Australia, Crawley, WA 6009, Australia
    • ,
  • F.R. Dunshea

      Affiliations

    • Melbourne School of Land and Environment, The University of Melbourne, Parkville, VIC 3010, Melbourne, Australia
    • ,
  • I.J. Clarke

      Affiliations

    • Department of Physiology, Building 13 F, Wellington Road, Monash University, VIC 3800, Australia

Received 14 May 2009 ,Revised 1 July 2009 ,Accepted 14 July 2009.

References 

  1. McEwen BS. Glucocorticoids, depression, and mood disorders: Structural remodeling in the brain. Metabolism. 2005;54:20–23
  2. McEwen BS. Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators. Eur J Pharmacol. 2008;583:174–185
  3. Nass R, Thorner MO. Impact of the gh-cortisol ratio on the age-dependent changes in body composition. Growth Horm IGF Res. 2002;12:147–161
  4. Epel E, Lapidus R, McEwen B, Brownell K. Stress may add bite to appetite in women: A laboratory study of stress-induced cortisol and eating behavior. Psychoneuroendocrinology. 2001;26:37–49
  5. Adam TC, Epel ES, Stress . eating and the reward system. Physiol Behav. 2007;91:449–458
  6. Livingstone DE, Kenyon CJ, Walker BR. Mechanisms of dysregulation of 11 beta-hydroxysteroid dehydrogenase type 1 in obese zucker rats. J Endocrinol. 2000;167:533–539
  7. Makimura H, Mizuno TM, Roberts J, Silverstein J, Beasley J, Mobbs CV. Adrenalectomy reverses obese phenotype and restores hypothalamic melanocortin tone in leptin-deficient ob/ob mice. Diabetes. 2000;49:1917–1923
  8. Engler D, Pham T, Fullerton MJ, Funder JW, Clarke IJ. Studies of the regulation of the hypothalamic-pituitary-adrenal axis in sheep with hypothalamic-pituitary disconnection. I. Effect of an audiovisual stimulus and insulin-induced hypoglycemia. Neuroendocrinology. 1988;48:551–560
  9. Lincoln GA, Rhind SM, Pompolo S, Clarke IJ. Hypothalamic control of photoperiod-induced cycles in food intake, body weight, and metabolic hormones in rams. Am J Physiol Regul Integr Comp Physiol. 2001;281:R76–R90
  10. Udden J, Bjorntorp P, Arner P, Barkeling B, Meurling L, Rossner S. Effects of glucocorticoids on leptin levels and eating behaviour in women. J Intern Med. 2003;253:225–231
  11. Jahng JW, Kim NY, Ryu V, et al. Dexamethasone reduces food intake, weight gain and the hypothalamic 5-ht concentration and increases plasma leptin in rats. Eur J Pharmacol. 2008;581:64–70
  12. Pecoraro N, Reyes F, Gomez F, Bhargava A, Dallman MF. Chronic stress promotes palatable feeding, which reduces signs of stress: Feedforward and feedback effects of chronic stress. Endocrinology. 2004;145:3754–3762
  13. Anukulkitch C, Rao A, Dunshea FR, Clarke IJ. A test of the lipostat theory in a seasonal (ovine) model under natural conditions reveals close relationship between adiposity and melanin concentrating hormone expression. Domest Anim Endocrinol. 2009;36:138–151
  14. Clarke IJ, Scott CJ, Rao A, Pompolo S, Barker-Gibb ML. Seasonal changes in the expression of neuropeptide y and pro-opiomelanocortin mrna in the arcuate nucleus of the ovariectomized ewe: Relationship to the seasonal appetite and breeding cycles. J Neuroendocrinol. 2000;12:1105–1111
  15. van Lier E, Perez-Clariget R, Forsberg M. Sex differences in cortisol secretion after administration of an acth analogue in sheep during the breeding and non-breeding season. Anim Reprod Sci. 2003;79:81–92
  16. Bocking AD, McMillen IC, Harding R, Thorburn GD. Effect of reduced uterine blood flow on fetal and maternal cortisol. J Dev Physiol. 1986;8:237–245
  17. Thomas GB, Cummins JT, Francis H, Sudbury AW, McCloud PI, Clarke IJ. Effect of restricted feeding on the relationship between hypophysial portal concentrations of growth hormone (gh)-releasing factor and somatostatin, and jugular concentrations of gh in ovariectomized ewes. Endocrinology. 1991;128:1151–1158
  18. Lee VW, Cumming IA, de Kretser DM, Findlay JK, Hudson B, Keogh EJ. Regulation of gonadotrophin secretion in rams from birth to sexual maturity. I. Plasma lh, fsh and testosterone levels. J Reprod Fertil. 1976;46:1–6
  19. Bremner WJ, Findlay JK, Lee VW, de Kretser DM, Cumming IA. Feedback effects of the testis on pituitary responsiveness to luteinizing hormone-releasing hormone infusions in the ram. Endocrinology. 1980;106:329–336
  20. Blache D, Tellam RL, Chagas LM, Blackberry MA, Vercoe PE, Martin GB. Level of nutrition affects leptin concentrations in plasma and cerebrospinal fluid in sheep. J Endocrinol. 2000;165:625–637
  21. Henry BA, Goding JW, Alexander WS, et al. Central administration of leptin to ovariectomized ewes inhibits food intake without affecting the secretion of hormones from the pituitary gland: Evidence for a dissociation of effects on appetite and neuroendocrine function. Endocrinology. 1999;140:1175–1182
  22. Clarke IJ. Variable patterns of gonadotropin-releasing hormone secretion during the estrogen-induced luteinizing hormone surge in ovariectomized ewes. Endocrinology. 1993;133:1624–1632
  23. Fletcher TP, Clarke IJ. Effects of hypothyroidism on the growth hormone axis in sheep. J Endocrinol. 1994;140:495–502
  24. Mercer JG, Tups A. Neuropeptides and anticipatory changes in behaviour and physiology: Seasonal body weight regulation in the siberian hamster. Eur J Pharmacol. 2003;480:43–50
  25. Clarke IJ. Models of “obesity” in large animals and birds. Front Horm Res. 2008;36:107–117
  26. Clarke IJ. Sex and season are major determinants of voluntary food intake in sheep. Reprod Fertil Dev. 2001;13:577–582
  27. Clarke IJ, Tilbrook AJ, Turner AI, Doughton BW, Goding JW. Sex, fat and the tilt of the earth: Effects of sex and season on the feeding response to centrally administered leptin in sheep. Endocrinology. 2001;142:2725–2728
  28. Sainsbury A, Cusin I, Rohner-Jeanrenaud F, Jeanrenaud B. Adrenalectomy prevents the obesity syndrome produced by chronic central neuropeptide y infusion in normal rats. Diabetes. 1997;46:209–214
  29. Teske JA, Billington CJ, Kotz CM. Neuropeptidergic mediators of spontaneous physical activity and non-exercise activity thermogenesis. Neuroendocrinology. 2008;87:71–90
  30. Ito M, Gomori A, Ishihara A, et al. Characterization of mch-mediated obesity in mice. Am J Physiol Endocrinol Metab. 2003;284:E940–E945
  31. Astrand A, Bohlooly YM, Larsdotter S, et al. Mice lacking melanin-concentrating hormone receptor 1 demonstrate increased heart rate associated with altered autonomic activity. Am J Physiol Regul Integr Comp Physiol. 2004;287:R749–R758
  32. Cataldi M, Magnan E, Guillaume V, et al. Acute stress stimulates secretion of ghrh and somatostatin into hypophysial portal blood of conscious sheep. Neurosci Lett. 1994;178:103–106
  33. Ting ST, Earley B, Crowe MA. Effect of cortisol infusion patterns and castration on metabolic and immunological indices of stress response in cattle. Domest Anim Endocrinol. 2004;26:329–349
  34. Thompson K, Coleman ES, Hudmon A, Kemppainen RJ, Soyoola EO, Sartin JL. Effects of short-term cortisol infusion on growth hormone-releasing hormone stimulation of growth hormone release in sheep. Am J Vet Res. 1995;56:1228–1231
  35. Breen KM, Karsch FJ. Does cortisol inhibit pulsatile luteinizing hormone secretion at the hypothalamic or pituitary level?. Endocrinology. 2004;145:692–698
  36. Breen KM, Stackpole CA, Clarke IJ, et al. Does the type ii glucocorticoid receptor mediate cortisol-induced suppression in pituitary responsiveness to gonadotropin-releasing hormone?. Endocrinology. 2004;145:2739–2746
  37. Pierce BN, Hemsworth PH, Rivalland ET, et al. Psychosocial stress suppresses attractivity, proceptivity and pulsatile lh secretion in the ewe. Horm Behav. 2008;54:424–434
  38. Stackpole CA, Turner AI, Clarke IJ, Lambert GW, Tilbrook AJ. Seasonal differences in the effect of isolation and restraint stress on the luteinizing hormone response to gonadotropin-releasing hormone in hypothalamopituitary disconnected, gonadectomized rams and ewes. Biol Reprod. 2003;69:1158–1164
  39. Oakley AE, Breen KM, Clarke IJ, Karsch FJ, Wagenmaker ER, Tilbrook AJ. Cortisol reduces gonadotropin-releasing hormone pulse frequency in follicular phase ewes: Influence of ovarian steroids. Endocrinology. 2009;150:341–349
  40. Oakley AE, Breen KM, Tilbrook AJ, Wagenmaker ER, Karsch FJ. Role of estradiol in cortisol-induced reduction of luteinizing hormone pulse frequency. Endocrinology. 2009;150:2775–2782
  41. Breen KM, Karsch FJ. Does season alter responsiveness of the reproductive neuroendocrine axis to the suppressive actions of cortisol in ovariectomized ewes?. Biol Reprod. 2006;74:41–45
  42. Franko KL, Giussani DA, Forhead AJ, Fowden AL. Effects of dexamethasone on the glucogenic capacity of fetal, pregnant, and non-pregnant adult sheep. J Endocrinol. 2007;192:67–73
  43. Kiess W, Englaro P, Hanitsch S, Rascher W, Attanasio A, Blum WF. High leptin concentrations in serum of very obese children are further stimulated by dexamethasone. Horm Metab Res. 1996;28:708–710
  44. Miell JP, Englaro P, Blum WF. Dexamethasone induces an acute and sustained rise in circulating leptin levels in normal human subjects. Horm Metab Res. 1996;28:704–707

PII: S0739-7240(09)00077-0

doi: 10.1016/j.domaniend.2009.07.006

Domestic Animal Endocrinology
Volume 38, Issue 1 , Pages 46-56 , January 2010

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