Domestic Animal Endocrinology
Volume 38, Issue 2 , Pages 103-114 , February 2010

Evidence for a potential role of neuropeptide Y in ovine corpus luteum function

  • C.S. Keator

      Affiliations

    • Department of Animal Science, University of Connecticut, Storrs, CT 06269
    • Corresponding Author InformationCorresponding author. Tel.: +1 503 614 3780; fax: +1 503 690 5563.
    • ,
  • E.E. Custer

      Affiliations

    • Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01655
    • ,
  • T.A. Hoagland

      Affiliations

    • Department of Animal Science, University of Connecticut, Storrs, CT 06269
    • ,
  • D.T. Schreiber

      Affiliations

    • Department of Animal Science, University of Connecticut, Storrs, CT 06269
    • ,
  • K. Mah

      Affiliations

    • Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA
    • ,
  • A.M. Lawson

      Affiliations

    • Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA
    • ,
  • O.D. Slayden

      Affiliations

    • Division of Reproductive Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA
    • ,
  • J.A. McCracken

      Affiliations

    • Department of Animal Science, University of Connecticut, Storrs, CT 06269

Received 8 January 2009 ,Revised 6 August 2009 ,Accepted 7 August 2009.

References 

  1. Tatemoto K, Carlquist M, Mutt V. Neuropeptide Y—a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide. Nature. 1982;296:659–660
  2. Markiewicz W, Jaroszewski JJ, Bossowska A, Majewski M. NPY: its occurrence and relevance in the female reproductive system. Folia Histochem Cytobiol. 2003;41:183–192
  3. Wojcik-Gladysz A, Polkowska J. Neuropeptide Y--a neuromodulatory link between nutrition and reproduction at the central nervous system level. Reprod Biol. 2006;6(Suppl 2):21–28
  4. DiBona GF, Neuropeptide Y. Am J Physiol Regul Integr Comp Physiol. 2002;282:R635–R636
  5. Grove KL, Smith MS. Ontogeny of the hypothalamic neuropeptide Y system. Physiol Behav. 2003;79:47–63
  6. Williams G, Cai XJ, Elliott JC, Harrold JA. Anabolic neuropeptides. Physiol Behav. 2004;81:211–222
  7. Advis JP, Klein J, Kuljis RO, Sarkar DK, McDonald JM, Conover CA. Regulation of gonadotropin releasing hormone release by neuropeptide Y at the median eminence during the preovulatory period in ewes. Neuroendocrinology. 2003;77:246–257
  8. Barker-Gibb ML, Scott CJ, Boublik JH, Clarke IJ. The role of neuropeptide Y (NPY) in the control of LH secretion in the ewe with respect to season, NPY receptor subtype and the site of action in the hypothalamus. J Endocrinol. 1995;147:565–579
  9. Barker-Gibb ML, Clarke IJ. Effect of season on neuropeptide Y and galanin within the hypothalamus of the ewe in relation to plasma luteinizing hormone concentrations and the breeding season: an immunohistochemical analysis. J Neuroendocrinol. 2000;12:618–626
  10. Wojcik-Gladysz A, Misztal T, Wankowska M, Romanowicz K, Polkowska J. Effect of central infusions of neuropeptide Y on GnRH/LH axis in ewes during the early anoestrous period. Reprod Biol. 2003;3:29–46
  11. Hulshof SC, Dijkstra G, Van der Beek EM, Bevers MM, Figueiredo JR, Beckers JF, et al. Immunocytochemical localization of vasoactive intestinal peptide and neuropeptide Y in the bovine ovary. Biol Reprod. 1994;50:553–560
  12. Majewski M, Kaleczyc J, Sienkiewicz W, Lakomy M. Existence and co-existence of vasoactive substances in nerve fibres supplying the abdomino-pelvic arterial tree of the female pig and cow. Acta Histochem. 1995;97:235–256
  13. Jorgensen JC, Sheikh SP, Forman A, Norgard M, Schwartz TW, Ottesen B, et al. Y in the human female genital tract: localization and biological action. Am J Physiol. 1989;257:E220–E227
  14. Jorgensen JC. Neuropeptide Y in mammalian genital tract: localization and biological action. Dan Med Bull. 1994;41:294–305
  15. Baranowska B, Chmielowska M, Radzikowska M, Borowiec M, Roguski K, Wasilewska-Dziubinska E. Effects of neuropeptide Y (NPY), galanin and vasoactive intestinal peptide (VIP) on pituitary hormone release and on ovarian steroidogenesis. Neuro Endocrinol Lett. 1999;20:385–389
  16. Barreca A, Valli B, Cesarone A, Arvigo M, Balasini M, La Battista SG, et al. Effects of the neuropeptide Y on estradiol and progesterone secretion by human granulosa cells in culture. Fertil Steril. 1998;70:320–325
  17. Miyamoto A, Bruckmann A, von LH, Schams D. Multiple effects of neuropeptide Y, substance P and vasoactive intestinal polypeptide on progesterone and oxytocin release from bovine corpus luteum in vitro. J Endocrinol. 1993;138:451–458
  18. Oliveros L, Forneris M, Aguado L. Secretion from neuropeptide-treated splenocytes modifies ovarian steroidogenesis. Medicina (B Aires). 2001;61:35–40
  19. Pitzel L, Jarry H, Wuttke W. Effects of substance-P and neuropeptide-Y on in vitro steroid release by porcine granulosa and luteal cells. Endocrinology. 1991;129:1059–1065
  20. Parker SL, Crowley WR. Central stimulation of oxytocin release in the lactating rat: interaction of neuropeptide Y with alpha-1-adrenergic mechanisms. Endocrinology. 1993;132:658–666
  21. Ivell R, Hunt N, Abend N, Brackman B, Nollmeyer D, Lamsa JC, et al. Structure and ovarian expression of the oxytocin gene in sheep. Reprod Fertil Dev. 1990;2:703–711
  22. Custer EE, Lamsa JC, Eldering JA, McCracken JA. In vivo dynamics of oxytocin secretion by the ovine corpus luteum. Adv Exp Med Biol. 1995;395:539–540
  23. McIntush EW, Pletz JD, Smith GD, Long DK, Sawyer HR, Smith MF. Immunolocalization of tissue inhibitor of metalloproteinases-1 within ovine periovulatory follicular and luteal tissues. Biol Reprod. 1996;54:871–878
  24. Lamsa JC, Kot SJ, Eldering JA, Nay MG, McCracken JA, Prostaglandin . F2 alpha-stimulated release of ovarian oxytocin in the sheep in vivo: threshold and dose dependency. Biol Reprod. 1989;40:1215–1223
  25. McCracken JA, Custer EE, Lamsa JC. Luteolysis: a neuroendocrine-mediated event. Physiol Rev. 1999;79:263–323
  26. Goding JR, McCracken JA, Baird DT. The study of ovarian function in the ewe by means of a vascular autotransplantation technique. J Endocrinol. 1967;39:37–52
  27. McCracken JA, Uno A, Goding JR, Ichikawa Y, Baird DT. The in-vivo effects of sheep pituitary gonadotrophins on the secretion of steroids by the autotransplanted ovary of the ewe. J Endocrinol. 1969;45:425–440
  28. Miyamoto A, Shirasuna K, Wijayagunawardane MP, Watanabe S, Hayashi M, Yamamoto D, et al. Blood flow: a key regulatory component of corpus luteum function in the cow. Domest Anim Endocrinol. 2005;29:329–339
  29. McCracken JA. Prostaglandin F2a: The luteolytic hormone. In:  Curtis-Prior P editors. The Eicosanoids. New York, NY: John Wiley & Sons; 2004;p. 525–545
  30. Majewski M, Heym C. The origin of ovarian neuropeptide Y (NPY)-immunoreactive nerve fibres from the inferior mesenteric ganglion in the pig. Cell Tissue Res. 1991;266:591–596
  31. McCracken JA, Carlson JC, Glew ME, Goding JR, Baird DT, Green K, et al. Prostaglandin F 2 identified as a luteolytic hormone in sheep. Nat New Biol. 1972;238:129–134
  32. Keator CS, Schreiber DT, Hoagland TA, McCracken JA. Luteotrophic and luteolytic effects of nitric oxide in sheep are dose-dependent in vivo. Domest Anim Endocrinol. 2008;35:74–80
  33. Ojeda SR, Urbanski HF. Puberty in the Rat. In:  Knobil E,  Neil JD editor. The Physiology of Reproduction. New York: Raven Press; 1988;p. 1699–1737
  34. Anesetti G, Lombide P, D’Albora H, Ojeda SR. Intrinsic neurons in the human ovary. Cell Tissue Res. 2001;306:231–237
  35. D’Albora H, Anesetti G, Lombide P, Dees WL, Ojeda SR. Intrinsic neurons in the mammalian ovary. Microsc Res Tech. 2002;59:484–489
  36. Loesch A. Perivascular nerves and vascular endothelium: recent advances. Histol Histopathol. 2002;17:591–597
  37. Movafagh S, Hobson JP, Spiegel S, Kleinman HK, Zukowska Z, Neuropeptide . Y induces migration, proliferation, and tube formation of endothelial cells bimodally via Y1, Y2, and Y5 receptors. FASEB J. 2006;20:1924–1926
  38. Qureshi NU, Dayao EK, Shirali S, Zukowska-Grojec Z, Hauser GJ. Endogenous neuropeptide Y mediates vasoconstriction during endotoxic and hemorrhagic shock. Regul Pept. 1998;75–76:215–220
  39. Zukowska-Grojec Z, Neuropeptide Y. A novel sympathetic stress hormone and more. Ann N Y Acad Sci. 1995;771:219–233
  40. Zukowska Z, Pons J, Lee EW, Li L. Neuropeptide Y: a new mediator linking sympathetic nerves, blood vessels and immune system?. Can J Physiol Pharmacol. 2003;81:89–94
  41. Ghersi G, Chen W, Lee EW, Zukowska Z. Critical role of dipeptidyl peptidase IV in neuropeptide Y-mediated endothelial cell migration in response to wounding. Peptides. 2001;22:453–458
  42. Nan YS, Feng GG, Hotta Y, Nishiwaki K, Shimada Y, Ishikawa A, et al. enhances permeability across a rat aortic endothelial cell monolayer. Am J Physiol Heart Circ Physiol. 2004;286:H1027–H1033
  43. Kurimoto N, Nan YS, Chen ZY, Feng GG, Komatsu T, Kandatsu N, et al. Effects of specific signal transduction inhibitors on increased permeability across rat endothelial monolayers induced by neuropeptide Y or VEGF. Am J Physiol Heart Circ Physiol. 2004;287:H100–H106
  44. Rodgers RJ, O'Shea JD, Bruce NW. Morphometric analysis of the cellular composition of the ovine corpus luteum. J Anat. 1984;138(Pt 4):757–770
  45. Heppner P, Lindner JR. Contrast ultrasound assessment of angiogenesis by perfusion and molecular imaging. Expert Rev Mol Diagn. 2005;5:447–455
  46. Holzer P. Neurogenic vasodilatation and plasma leakage in the skin. Gen Pharmacol. 1998;30:5–11
  47. Song CW, Park HJ, Lee CK, Griffin R. Implications of increased tumor blood flow and oxygenation caused by mild temperature hyperthermia in tumor treatment. Int J Hyperthermia. 2005;21:761–767
  48. Kaczmarek MM, Schams D, Ziecik AJ. Role of vascular endothelial growth factor in ovarian physiology - an overview. Reprod Biol. 2005;5:111–136
  49. Ehrhart-Bornstein M, Haidan A, Alesci S, Bornstein SR. Neurotransmitters and neuropeptides in the differential regulation of steroidogenesis in adrenocortical-chromaffin co-cultures. Endocr Res. 2000;26:833–842
  50. Jacques D, Sader S, Perreault C, Fournier A, Pelletier G, Beck-Sickinger AG, et al. Presence of neuropeptide Y and the Y1 receptor in the plasma membrane and nuclear envelope of human endocardial endothelial cells: modulation of intracellular calcium. Can J Physiol Pharmacol. 2003;81:288–300
  51. Jacques D, Abdel-Samad D, Neuropeptide Y . (NPY) and NPY receptors in the cardiovascular system: implication in the regulation of intracellular calcium. Can J Physiol Pharmacol. 2007;85:43–53
  52. Abdel-Samad D, Jacques D, Perreault C, Provost C. NPY regulates human endocardial endothelial cell function. Peptides. 2007;28:281–287
  53. Hinckley ST, Milvae RA. Endothelin-1 mediates prostaglandin F(2alpha)-induced luteal regression in the ewe. Biol Reprod. 2001;64:1619–1623
  54. Fabi F, Argiolas L, Ruvolo G, del Basso P. Neuropeptide Y-induced potentiation of noradrenergic vasoconstriction in the human saphenous vein: involvement of endothelium generated thromboxane. Br J Pharmacol. 1998;124:101–110
  55. Hoang D, Macarthur H, Gardner A, Westfall TC. Endothelin-induced modulation of neuropeptide Y and norepinephrine release from the rat mesenteric bed. Am J Physiol Heart Circ Physiol. 2002;283:H1523–H1530
  56. Ohtani M, Takase S, Wijayagunawardane MP, Tetsuka M, Miyamoto A. Local interaction of prostaglandin F 2alpha with endothelin-1 and tumor necrosis factor-alpha on the release of progesterone and oxytocin in ovine corpora lutea in vivo: a possible implication for a luteolytic cascade. Reproduction. 2004;127:117–124
  57. Bkaily G, Choufani S, Avedanian L, Ahmarani L, Nader M, Jacques D, et al. Nonpeptidic antagonists of ETA and ETB receptors reverse the ET-1-induced sustained increase of cytosolic and nuclear calcium in human aortic vascular smooth muscle cells. Can J Physiol Pharmacol. 2008;86:546–556
  58. Choudhary E, Costine BA, Wilson ME, Inskeep EK, Flores JA. Prostaglandin F2alpha (PGF2alpha) independent and dependent regulation of the bovine luteal endothelin system. Domest Anim Endocrinol. 2004;27:63–79
  59. Doerr MD, Goravanahally MP, Rhinehart JD, Inskeep EK, Flores JA. Effects of endothelin receptor type-A and type-B antagonists on prostaglandin F2alpha-induced luteolysis of the sheep corpus luteum. Biol Reprod. 2008;78:688–696

PII: S0739-7240(09)00096-4

doi: 10.1016/j.domaniend.2009.08.003

Domestic Animal Endocrinology
Volume 38, Issue 2 , Pages 103-114 , February 2010

Article Tools

* Image Usage & Resolution