Domestic Animal Endocrinology
Volume 38, Issue 3 , Pages 168-178 , April 2010

Adipose tissue depots of Holstein cows are immune responsive: Inflammatory gene expression in vitro

  • M. Mukesh

      Affiliations

    • Mammalian NutriPhysioGenomics, University of Illinois, Urbana, IL 61801
    • Department of Animal Sciences, University of Illinois, Urbana, IL 61801
    • ,
  • M. Bionaz

      Affiliations

    • Mammalian NutriPhysioGenomics, University of Illinois, Urbana, IL 61801
    • Department of Animal Sciences, University of Illinois, Urbana, IL 61801
    • ,
  • D.E. Graugnard

      Affiliations

    • Mammalian NutriPhysioGenomics, University of Illinois, Urbana, IL 61801
    • Department of Animal Sciences, University of Illinois, Urbana, IL 61801
    • ,
  • J.K. Drackley

      Affiliations

    • Department of Animal Sciences, University of Illinois, Urbana, IL 61801
    • Division of Nutritional Sciences, University of Illinois, Urbana, IL 61801, USA
    • ,
  • J.J. Loor

      Affiliations

    • Mammalian NutriPhysioGenomics, University of Illinois, Urbana, IL 61801
    • Department of Animal Sciences, University of Illinois, Urbana, IL 61801
    • Division of Nutritional Sciences, University of Illinois, Urbana, IL 61801, USA
    • Corresponding Author InformationCorresponding author at: Department of Animal Sciences, University of Illinois, 498 Animal Sciences Laboratory, 1207 West Gregory Dr, Urbana, IL 61801, USA. Tel.: +1 217 244 5957; fax: +1 217 333 8286.

Received 17 August 2009 ,Revised 20 September 2009 ,Accepted 6 October 2009.

References 

  1. Rosen ED, Spiegelman BM. Adipocytes as regulators of energy balance and glucose homeostasis. Nature. 2006;444:847–853
  2. Desruisseaux MS, Nagajyothi , Trujillo ME, Tanowitz HB, Scherer PE, Adipocyte . adipose tissue, and infectious disease. Infect Immun. 2007;75:1066–1078
  3. Pajvani UB, Trujillo ME, Combs TP, Iyengar P, Jelicks L, Roth KA, et al. Fat apoptosis through targeted activation of caspase 8: A new mouse model of inducible and reversible lipoatrophy. Nat Med. 2005;11:797–803
  4. Lu B, Lu Y, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR. Lps and proinflammatory cytokines decrease lipin-1 in mouse adipose tissue and 3t3-l1 adipocytes. Am J Physiol Endocrinol Metab. 2008;295:E1502–1509
  5. Drackley JK, Dann HM, Douglas GN, Janovick-Guretzky NA, Litherland NB, Underwood JP, et al. Physiological and pathological adaptations in dairy cows that may increase susceptibility to periparturient diseases and disorders. Ital J Anim Sci. 2005;4:323–344
  6. Lafontan M, Berlan M. Do regional differences in adipocyte biology provide new pathophysiological insights?. Trends Pharmacol Sci. 2003;24:276–283
  7. Drackley JK, Dann HM, Douglas GN, Janovick Guretzky NA, Litherland NB, Underwood JP, et al. Physiological and pathological adaptations in dairy cows that may increase susceptibility to periparturient diseases and disorders. Ital J Anim Sci. 2005;4:323–344
  8. Loor JJ, Dann HM, Janovick Guretzky NA, Everts RE, Oliveira R, Green CA, et al. Plane of nutrition prepartum alters hepatic gene expression and function in dairy cows as assessed by longitudinal transcript and metabolic profiling. Physiol Genom. 2006;27:29–41
  9. Loor JJ, Everts RE, Bionaz M, Dann HM, Oliveira R, Morin DE, et al. Nutrition-induced ketosis alters metabolic and signaling gene networks in liver from periparturient cows. Physiol Genomics. 2007;32:105–116
  10. Reue K, Zhang P. The lipin protein family: Dual roles in lipid biosynthesis and gene expression. FEBS Lett. 2008;582:90–96
  11. Nikkhah A, Loor JJ, Wallace L, Graugnard DE, Vasquez J, Richards B, et al. Moderate excesses of dietary energy markedly increase visceral adipose tissue mass in non-lactating dairy cows. J Dairy Sci. 2008;91:LB4
  12. Wildman EE, Jones GM, Wagner PE, Boman RL, Troutt HF, Lesch TN. A dairy cow body condition scoring system and its relationship to selected production characteristics. J Dairy Sci. 1982;65:495–501
  13. Bionaz M, Loor JJ. Identification of reference genes for quantitative real-time pcr in the bovine mammary gland during the lactation cycle. Physiol Genomics. 2007;29:312–319
  14. Piantoni P, Bionaz M, Graugnard DE, Daniels KM, Akers RM, Loor JJ. Gene expression ratio stability evaluation in prepubertal bovine mammary tissue from calves fed different milk replacers reveals novel internal controls for quantitative polymerase chain reaction. J Nutr. 2008;138:1158–1164
  15. Janovick NA, Loor JJ, Bionaz M, Lewin HA, Everts RE, Rodriguez-Zas SL, et al. Overfeeding energy prepartum dramatically affects peripartal expression of mrna transcripts in subcutaneous adipose tissue compared with controlling energy intake prepartum. J Dairy Sci. 2009;92:700
  16. Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, Speleman F., Accurate normalization of real-time quantitative rt-pcr data by geometric averaging of multiple internal control genes. Genome Biol. 2002; 3:RESEARCH0034.
  17. Menon R, Lombardi SJ, Fortunato SJ. Tnf-alpha promotes caspase activation and apoptosis in human fetal membranes. J Assist Reprod Genet. 2002;19:201–204
  18. Strianese D, Baldi G, Staibano S, Baldi A, De Rosa G, Tranfa F, et al. Expression of apoptosis-related markers in malignant epithelial tumours of the lacrimal gland and their relation to clinical outcome. Br J Ophthalmol. 2007;91:1239–1243
  19. Edwards JE, Huws SA, Kim EJ, Kingston-Smith AH. Characterization of the dynamics of initial bacterial colonization of nonconserved forage in the bovine rumen. FEMS Microbiol Ecol. 2007;62:323–335
  20. Sjoholm K, Palming J, Olofsson LE, Gummesson A, Svensson PA, Lystig TC, et al. A microarray search for genes predominantly expressed in human omental adipocytes: Adipose tissue as a major production site of serum amyloid a. J Clin Endocrinol Metab. 2005;90:2233–2239
  21. Lin Y, Rajala MW, Berger JP, Moller DE, Barzilai N, Scherer PE. Hyperglycemia-induced production of acute phase reactants in adipose tissue. J Biol Chem. 2001;276:42077–42083
  22. Bionaz M, Loor JJ, Acsl1 . agpat6, fabp3, lpin1, and slc27a6 are the most abundant isoforms in bovine mammary tissue and their expression is affected by stage of lactation. J Nutr. 2008;138:1019–1024
  23. Bruun JM, Lihn AS, Pedersen SB, Richelsen B. Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue (at): Implication of macrophages resident in the at. J Clin Endocrinol Metab. 2005;90:2282–2289
  24. Hishikawa D, Hong YH, Roh SG, Miyahara H, Nishimura Y, Tomimatsu A, et al. Identification of genes expressed differentially in subcutaneous and visceral fat of cattle, pig, and mouse. Physiol Genomics. 2005;21:343–350
  25. Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, Flier JS. Tlr4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest. 2006;116:3015–3025
  26. Sartipy P, Loskutoff DJ. Expression profiling identifies genes that continue to respond to insulin in adipocytes made insulin-resistant by treatment with tumor necrosis factor-alpha. J Biol Chem. 2003;278:52298–52306
  27. Madani R, Karastergiou K, Ogston N, Miheisi N, Bhome R, Haloob N, et al. RANTES release by human adipose tissue in vivo and evidence for depot specific differences. Am J Physiol Endocrinol Metab. 2009;296:E1262–1268
  28. Poitou C, Divoux A, Faty A, Tordjman J, Hugol D, Aissat A, et al. Role of serum amyloid a in adipocyte-macrophage cross talk and adipocyte cholesterol efflux. J Clin Endocrinol Metab. 2009;94:1810–1817
  29. Meek RL, Eriksen N, Benditt EP. Serum amyloid A in the mouse. Sites of uptake and mRNA expression. Am J Pathol. 1989;135:411–419
  30. Chiba T, Han CY, Vaisar T, Shimokado K, Kargi A, Chen MH, et al. Serum amyloid A3 does not contribute to circulating SAA levels. J Lipid Res. 2009;50:1353–1362
  31. Han CY, Subramanian S, Chan CK, Omer M, Chiba T, Wight TN, et al. Adipocyte-derived serum amyloid A3 and hyaluronan play a role in monocyte recruitment and adhesion. Diabetes. 2007;56:2260–2273
  32. Molenaar AJ, Harris DP, Rajan GH, Pearson ML, Callaghan MR, Sommer L, et al. The acute-phase protein serum amyloid A3 is expressed in the bovine mammary gland and plays a role in host defence. Biomarkers. 2009;14:26–37
  33. Larson MA, Weber A, McDonald TL. Bovine serum amyloid A3 gene structure and promoter analysis: induced transcriptional expression by bacterial components and the hormone prolactin. Gene. 2006;380:104–110
  34. Benditt EP, Meek RL. Expression of the third member of the serum amyloid A gene family in mouse adipocytes. J Exp Med. 1989;169:1841–1846
  35. Sjoholm K, Palming J, Olofsson LE, Gummesson A, Svensson PA, Lystig TC, et al. A microarray search for genes predominantly expressed in human omental adipocytes: Adipose tissue as a major production site of serum amyloid a. J Clin Endocrinol Metab. 2005;90:2233–2239
  36. Ametaj BN, Bradford BJ, Bobe G, Nafikov RA, Lu Y, Young JW, et al. Strong relationships between mediators of the acute phase response and fatty liver in dairy cows. Can J Anim Sci. 2005;85:165–175
  37. Khovidhunkit W, Kim MS, Memon RA, Shigenaga JK, Moser AH, Feingold KR, et al. Effects of infection and inflammation on lipid and lipoprotein metabolism: Mechanisms and consequences to the host. J Lipid Res. 2004;45:1169–1196
  38. Feingold KR, Grunfeld C. Role of cytokines in inducing hyperlipidemia. Diabetes. 1992;41(Suppl 2):97–101
  39. Hotamisligil GS. Molecular mechanisms of insulin resistance and the role of the adipocyte. Int J Obes Relat Metab Disord. 2000;24(Suppl 4):S23–27
  40. Maeda N, Shimomura I, Kishida K, Nishizawa H, Matsuda M, Nagaretani H, et al. Diet-induced insulin resistance in mice lacking adiponectin/acrp30. Nat Med. 2002;8:731–737
  41. Yamashita A, Soga Y, Iwamoto Y, Asano T, Li Y, Abiko Y, et al. DNA microarray analyses of genes expressed differentially in 3t3-l1 adipocytes co-cultured with murine macrophage cell line raw264.7 in the presence of the toll-like receptor 4 ligand bacterial endotoxin. Int J Obes (Lond). 2008;32:1725–1729
  42. Hakogi E, Tamura H, Tanaka S, Kohata A, Shimada Y, Tabuchi K. Endotoxin levels in milk and plasma of mastitis-affected cows measured with a chromogenic limulus test. Vet Microbiol. 1989;20:267–274
  43. Cuschieri J, Gourlay D, Garcia I, Jelacic S, Maier RV. Hypertonic preconditioning inhibits macrophage responsiveness to endotoxin. J Immunol. 2002;168:1389–1396
  44. Kennedy MT, Higgins BD, Costello JF, Curtin WA, Laffey JG. Hypertonic saline reduces inflammation and enhances the resolution of oleic acid induced acute lung injury. BMC Pulm Med. 2008;8:9

PII: S0739-7240(09)00117-9

doi: 10.1016/j.domaniend.2009.10.001

Domestic Animal Endocrinology
Volume 38, Issue 3 , Pages 168-178 , April 2010

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