Domestic Animal Endocrinology
Volume 38, Issue 4 , Pages 253-259 , May 2010

Platelet-derived growth factor acts via both the Rho-kinase and p38 signaling enzymes to stimulate contraction in an in vitro model of equine wound healing

Received 17 August 2009 ,Revised 20 October 2009 ,Accepted 12 November 2009.

References 

  1. Wilmink JM, van Weeren PR. Second-intention repair in the horse and pony and management of exuberant granulation tissue. Vet Clin North Am Equine Pract. 2005;21:15–32
  2. Knottenbelt DC. Equine wound management: are there significant differences in healing at different sites on the body?. Vet Dermatol. 1997;8:273–290
  3. Hakkinen L, Uitto VJ, Larjava H. Cell biology of gingival wound healing. Periodontol. 2000;24:127–152
  4. Wilmink JM, Nederbragt H, van Weeren PR, Stolk PW, Barneveld A. Differences in wound contraction between horses and ponies: the in vitro contraction capacity of fibroblasts. Equine Vet J. 2001;33:499–505
  5. Ehrlich H, Sun B, Kainth KS, Kromah F. Elucidating the mechanism of wound contraction: rapid versus sustained myosin ATPase activity in attached-delayed-released compared with free-floating fibroblast-populated collagen lattices. Wound Repair Regen. 2006;14:625–632
  6. Theoret CL. The pathophysiology of wound repair. Vet Clin North Am Equine Pract. 2001;21:1–13
  7. Li S, Moon JJ, Miao H, et al. Signal transduction in matrix contraction and the migration of vascular smooth muscle cells in three-dimensional matrix. J Vasc Res. 2003;40:378–388
  8. Tamariz E, Grinnell F. Modulation of fibroblast morphology and adhesion during collagen matrix remodeling. Mol Biol Cell. 2002;13:3915–3929
  9. Hirano S, Rees RS, Gilmont RR. MAP kinase pathways involving hsp27 regulate fibroblast-mediated wound contraction. J Surg Res. 2002;102:77–84
  10. Hinz B. Masters and servants of the force: the role of matrix adhesions in myofibroblast force perception and transmission. Eur J Cell Biol. 2006;85:175–181
  11. Serini G, Bochaton-Piallat ML, Ropraz P, et al. The fibronectin domain ED-A is crucial for myofibroblastic phenotype induction by transforming growth factor-beta1. J Cell Biol. 1998;142:873–881
  12. Chipev CC, Simon M. Phenotypic differences between dermal fibroblasts from different body sites determine their responses to tension and TGFbeta1. BMC Dermatol. 2002;2:13
  13. Goffin JM, Pittet P, Csucs G, Lussi JW, Meister JJ, Hinz B. Focal adhesion size controls tension-dependent recruitment of alpha-smooth muscle actin to stress fibers. J Cell Biol. 2002;172:259–268
  14. Grinnell F. Fibroblasts, myofibroblasts, and wound contraction. J Cell Biol. 1994;124:401–404
  15. Arora PD, Narani N, Mcculloch CA. The compliance of collagen gels regulates transforming growth factor-beta induction of alpha-smooth muscle actin in fibroblasts. Am J Pathol. 1999;154:871–882
  16. Andresen JL, Ledet T, Ehlers N. Keratocyte migration and peptide growth factors: the effect of PDGF, bFGF, EGF, IGF-I, aFGF and TGF-beta on human keratocyte migration in a collagen gel. Curr Eye Res. 1997;16:605–613
  17. Lee YR, Oshita Y, Tsuboi R, Ogawa H. Combination of insulin-like growth factor (IGF)-I and IGF-binding protein-1 promotes fibroblast-embedded collagen gel contraction. Endocrinology. 1996;137:5278–5283
  18. Davies SP, Reddy H, Caivano M, Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000;351:95–105
  19. Assouline M, Chew SJ, Thompson HW, Beuerman R. Effect of growth factors on collagen lattice contraction by human keratocytes. Invest Ophthalmol Vis Sci. 1992;133:1742–1755
  20. Clark RA. Fibronectin matrix deposition and fibronectin receptor expression in healing and normal skin. J Invest Dermatol. 1990;94:128S–134S
  21. Jeschke MG, Schubert T, Krickhahn M, et al. Interaction of exogenous liposomal insulin-like growth factor-I cDNA gene transfer with growth factors on collagen expression in acute wounds. Wound Repair Regen. 2005;13:269–277
  22. Edmondson SR, Thumiger SP, Werther GA, Wraight CJ. Epidermal homeostasis: the role of the growth hormone and insulin-like growth factor systems. Endocr Rev. 2003;24:737–764
  23. Kanekar S, Borg TK, Terracio L, Carver W. Modulation of heart fibroblast migration and collagen gel contraction by IGF-I. Cell Adhes Commun. 2000;7:513–523
  24. Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C, Brown RA. Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol. 2002;3:349–363
  25. Ellis IR, Schor SL. Differential motogenic and biosynthetic response of fetal and adult skin fibroblasts to TGF-beta isoforms. Cytokine. 1998;10:281–289
  26. Montesano R, Orci L. Transforming growth factor beta stimulates collagen-matrix contraction by fibroblasts: implications for wound healing. Proc Natl Acad Sci U S A. 1988;85:4894–4897
  27. Haber M, Cao Z, Panjwani N, Bedenice D, Li WW, Provost PJ. Effects of growth factors (EGF. PDGF-BB and TGF-beta 1) on cultured equine epithelial cells and keratocytes: implications for wound healing. Vet Ophthalmol. 2003;6:211–217
  28. Cochrane CA, Freeman KL, Knottenbelt DC. Effect of growth factors on the characteristics of cells associated with equine wound healing and sarcoid formation. Wound Repair Regen. 1996;4:58–65
  29. Nixon AJ, Brower-Toland BD, Sandell LJ. Molecular cloning of equine transforming growth factor-beta1 reveals equine-specific amino acid substitutions in the mature peptide sequence. J Mol Endocrinol. 2000;24:261–272
  30. Lee HG, Eun HC. Differences between fibroblasts cultured from oral mucosa and normal skin: implication to wound healing. J Dermatol Sci. 1999;21:176–182
  31. Hall A, Rho . GTPases and the control of cell behaviour. Biochem Soc Trans. 2005;33:891–895
  32. Hotchin NA, Hall A. The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases. J Cell Biol. 1995;131:1857–1865
  33. Hinz B, Gabbiani G. Mechanisms of force generation and transmission by myofibroblasts. Curr Opin Biotechnol. 2003;14:538–546
  34. Bhadriraju K, Yang M, Alom Ruiz S, Pirone D, Tan J, Chen CS. Activation of ROCK by RhoA is regulated by cell adhesion, shape, and cytoskeletal tension. Exp Cell Res. 2007;313:3616–3623
  35. Grinnell F. Fibroblast-collagen-matrix contraction: growth-factor signalling and mechanical loading. Trends Cell Biol. 2000;10:362–365
  36. Amano M, Kaneko T, Maeda A, et al. Identification of Tau and MAP2 as novel substrates of Rho-kinase and myosin phosphatase. J Neurochem. 2003;87:780–790
  37. Ehrlich HP, Rittenberg T. Differences in the mechanism for high- versus moderate-density fibroblast-populated collagen lattice contraction. J Cell Physiol. 2000;185:432–439
  38. Darenfed H, Dayanandan B, Zhang T, Hsieh SH, Fournier AE, Mandato CA. Molecular characterization of the effects of Y-27632. Cell Motil Cytoskeleton. 2007;64:97–109

PII: S0739-7240(09)00147-7

doi: 10.1016/j.domaniend.2009.11.004

Domestic Animal Endocrinology
Volume 38, Issue 4 , Pages 253-259 , May 2010