Domestic Animal Endocrinology
Volume 38, Issue 4 , Pages 272-283 , May 2010

Effects of unsaturated fatty acids on progesterone secretion and selected protein kinases in goat granulosa cells

  • S. Coyral-Castel
    • ,
  • C. Ramé
    • ,
  • A. Fatet
    • ,
  • J. Dupont

      Affiliations

    • Corresponding Author InformationCorresponding author at: Unité de Physiologie de la Reproduction et des Comportements, Institut National de la Recherche Agronomique, 37380 Nouzilly, France. Tel.: +33 2 47 42 77 89; fax: +33 2 47 42 77 43.

Received 9 September 2009 ,Revised 15 December 2009 ,Accepted 17 December 2009.

References 

  1. Gurr MI, Harwood JL, Frayn KN. Lipid Biochemistry: An Introduction. 5th ed.. London: Blackwell Science, Ltd.; 2002;
  2. Bilby TR, Block J, do Amaral BC, Sa O, Silvestre FT, Hansen PJ, et al. Effects of dietary unsaturated fatty acids on oocyte quality and follicular development in lactating dairy cows in summer. J Dairy Sci. 2006;89:3891–3903
  3. Ambrose DJ, Kastelic JP, Corbett R, Pitney PA, Petit HV, Small JA, et al. Lower pregnancy losses in lactating dairy cows fed a diet enriched in alpha-linolenic acid. J Dairy Sci. 2006;89:3066–3074
  4. Zachut M, Arieli A, Lehrer H, Argov N, Moallem U. Dietary unsaturated fatty acids influence preovulatory follicle characteristics in dairy cows. Reproduction. 2008;135:683–692
  5. Hinckley T, Clark RM, Bushmich SL, Milvae RA. Long chain polyunsaturated fatty acids and bovine luteal cell function. Biol Reprod. 1996;55:445–449
  6. Vanholder T, Leroy J, Van Soom A, Opsomer G, Maes D, Coryn M, et al. Effect of non-esterified fatty acids on bovine granulosa cell steroidogenesis and proliferation in vitro. Anim Reprod Sci. 2005;87:33–44
  7. Wehrman ME, Welsh TH, Williams GL. Diet-induced hyperlipidemia in cattle modifies the intrafollicular cholesterol environment, modulates ovarian follicular dynamics, and hastens the onset of postpartum luteal activity. Biol Reprod. 1991;45:514–522
  8. Yu YS, Li W, Han ZB, Luo MJ, Chang ZL, Tan JH. The effect of follicle-stimulating hormone on follicular development, granulosa cell apoptosis and steroidogenesis and its mediation by insulin-like growth factor-1 in the goat ovary. Theriogenology. 2003;60:1691–1704
  9. Gyles SL, Burns CJ, Whitehouse BJ, Sugden D, Marsh PJ, Persaud SJ, et al. Erks regulate cyclic amp-induced steroid synthesis through transcription of the steroidogenic acute regulatory (star) gene. J Biol Chem. 2001;276:34888–34895
  10. Tosca L, Froment P, Solnais P, Ferre P, Foufelle F, Dupont J. Adenosine 5′-monophosphate-activated protein kinase regulates progesterone secretion in rat granulosa cells. Endocrinology. 2005;146:4500–4513
  11. Tosca L, Chabrolle C, Uzbekova S, Dupont J. Effects of metformin on bovine granulosa cells steroidogenesis: Possible involvement of adenosine 5’-monophosphate-activated protein kinase (AMPK). Biol Reprod. 2007;76:368–378
  12. Tosca L, Crochet S, Ferre P, Foufelle F, Tesseraud S, Dupont J. AMP-activated protein kinase activation modulates progesterone secretion in granulosa cells from hen preovulatory follicles. J Endocrinol. 2006;190:85–97
  13. Seger R, Krebs EG. The MAPK signaling cascade. FASEB J. 1995;9:726–735
  14. Pearson G, Robinson F, Gibson TB, Xu BE, Karandikar M, Berman K, et al. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev. 2001;22:153–183
  15. Cameron MR, Foster JS, Bukovsky A, Wimalasena J. Activation of mitogen-activated protein kinases by gonadotropins and cyclic adenosine 5′-monophosphates in porcine granulosa cells. Biol Reprod. 1996;55:111–119
  16. Das S, Maizels ET, DeManno D, St. Clair E, Adam SA, HunzickerDunn M. A stimulatory role of cyclic adenosine 3′,5′-monophosphate in follicle-stimulating hormone-activated mitogen-activated protein kinase signaling pathway in rat ovarian granulosa cells. Endocrinology. 1996;137:967–974
  17. Seger R, Hanoch T, Rosenberg R, Dantes A, Merz WE, Strauss JF, et al. The ERK signaling cascade inhibits gonadotropin-stimulated steroidogenesis. J Biol Chem. 2001;276:13957–13964
  18. Carling D. The AMP-activated protein kinase cascade: a unifying system for energy control. Trends Biochem Sci. 2004;29:18–24
  19. Stein SC, Woods A, Jones NA, Davison MD, Carling D. The regulation of AMP-activated protein kinase by phosphorylation. Biochem J. 2000;345:437–443
  20. Tosca L, Solnais P, Ferre P, Foufelle F, Dupont J. Metformin-induced stimulation of adenosine 5’-monophosphate-activated protein kinase (PRKA) impairs progesterone secretion in rat granulosa cells. Biol Reprod. 2006;75:342–351
  21. Botolin D, Wang Y, Christian B, Jump DB. Docosahexaneoic acid (22: 6, n-3) regulates rat hepatocyte srebp-1 nuclear abundance by ERK- and 26s proteasome-dependent pathways. J Lipid Res. 2006;47:181–192
  22. Yonezawa T, Haga S, Kobayashi Y, Katoh K, Obara Y. Unsaturated fatty acids promote proliferation via ERK1/2 and AKT pathway in bovine mammary epithelial cells. Biochem Biophys Res Commun. 2008;367:729–735
  23. Kawaguchi T, Osatomi K, Yamashita H, Kabashima T, Uyeda K. Mechanism for fatty acid “sparing” effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase. J Biol Chem. 2002;277:3829–3835
  24. Behl R, Pandey RS. Effect of recombinant insulin like growth factor-1 on caprine granulosa cell steroidogenesis, in vitro. Small Ruminant Res. 1999;33:165–169
  25. Robinson RS, Pushpakumara PGA, Cheng Z, Peters AR, Abayasekara DRE, Wathes DC. Effects of dietary polyunsaturated fatty acids on ovarian and uterine function in lactating dairy cows. Reproduction. 2002;124:119–131
  26. Basini G, Baratta M, Bussolati S, Tamanini C. Interleukin-1 beta fragment (163-171) modulates bovine granulosa cell proliferation in vitro: dependence on size of follicle. J Reprod Immunol. 1998;37:139–153
  27. Spicer LJ, Alpizar E, Echternkamp SE. Effects of insulin, insulin-like growth factor-1, and gonadotropins on bovine granulosa-cell proliferation, progesterone production, estradiol production, and (or) insulin-like growth factor-1 production in vitro. J Anim Sci. 1993;71:1232–1241
  28. Monniaux D, Pisselet C. Control of proliferation and differentiation of ovine granulosa-cells by insulin-like growth factor-1 and follicle-stimulating-hormone in vitro. Biol Reprod. 1992;46:109–119
  29. Zhang Q, Bagnell CA. Relaxin stimulation of porcine granulosa-cell deoxyribonucleic-acid synthesis in vitro: interactions with insulin and insulin-like growth factor-1. Endocrinology. 1993;132:1643–1650
  30. Amaru DL, Field CJ. Conjugated linoleic acid decreases MCF-7 human breast cancer cell growth and insulin-like growth factor-1 receptor levels. Lipids. 2009;44:449–458
  31. Bilodeau-Goeseels S, Sasseville M, Guillemette C, Richard FJ. Effects of adenosine monophosphate-activated kinase activators on bovine oocyte nuclear maturation in vitro. Mol Reprod Dev. 2007;74:1021–1034
  32. Durante PE, Mustard KJ, Park SH, Winder WW, Hardie DG. Effects of endurance training on activity and expression of AMP-activated protein kinase isoforms in rat muscles. Am J Physiol Endocrinol Metab. 2002;283:E178–E186
  33. Nielsen JN, Mustard KJW, Graham DA, Yu HY, MacDonald CS, Pilegaard H, et al. 5′-AMP-activated protein kinase activity and subunit expression in exercise-trained human skeletal muscle. J Appl Physiol. 2003;94:631–641
  34. Tajima K, Yoshii K, Fukuda S, Orisaka M, Miyamoto K, Amsterdam A, et al. Luteinizing hormone-induced extracellular-signal regulated kinase activation differently modulates progesterone and androstenedione production in bovine theca cells. Endocrinology. 2005;146:2903–2910
  35. Schopfer FJ, Lin YM, Baker PRS, Cui TX, Garcia-Barrio M, Zhang JF, et al. Nitrolinoleic acid: an endogenous peroxisome proliferator-activated receptor gamma ligand. Proc Natl Acad Sci U S A. 2005;102:2340–2345
  36. Burns KA, Heuvel JPV. Modulation of PPAR activity via phosphorylation. Biochim Biophys Acta Mol Cell Biol Lipids. 2007;1771:952–960

PII: S0739-7240(10)00002-0

doi: 10.1016/j.domaniend.2009.12.002

Domestic Animal Endocrinology
Volume 38, Issue 4 , Pages 272-283 , May 2010

Article Tools

* Image Usage & Resolution