Domestic Animal Endocrinology
Volume 39, Issue 3 , Pages 163-170 , October 2010

Oxyntomodulin increases the concentrations of insulin and glucose in plasma but does not affect ghrelin secretion in Holstein cattle under normal physiological conditions

  • S. ThanThan

      Affiliations

    • Department of Life Science and Agriculture, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Japan
    • ,
  • H. Zhao

      Affiliations

    • Department of Life Science and Agriculture, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Japan
    • ,
  • S. Yannaing

      Affiliations

    • Department of Life Science and Agriculture, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Japan
    • ,
  • T. Ishikawa

      Affiliations

    • Division of Biomedical Science, Department of Basic Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Japan
    • ,
  • H. Kuwayama

      Affiliations

    • Department of Life Science and Agriculture, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Japan
    • Corresponding Author InformationAddress for correspondence: Department of Life Science and Agriculture, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro 080-8555, Japan; Phone: +81 155 49 5434; Fax: +81 155 49 5434

References 

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  2. Wren AM, Small CJ, Ward HL, Murphy KG, Dakin CL, Taheri S, et al. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology. 2000;141:4325–4328
  3. ThidarMyint H, Yoshida H, Ito T, Kuwayama H. Dose-dependent response of plasma ghrelin and growth hormone concentrations to bovine ghrelin in Holstein heifers. J Endocrinol. 2006;189:655–664
  4. ThidarMyint H, Yoshida H, Ito T, He M, Inoue H, Kuwayama H. Combined administration of ghrelin and GHRH synergistically stimulates GH release in Holstein preweaning calves. Domest Anim Endocrinol. 2007;34:118–123
  5. Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, et al. A role for ghrelin in the central regulation of feeding. Nature. 2001;409:194–198
  6. ThanThan S, Mekaru C, Seki N, Hidaka K, Ueno A, ThidarMyint H, et al. Endogenous ghrelin released in response to endothelin stimulates growth hormone secretion in cattle. Domest Anim Endocrinol. 2010;38:1–12
  7. Katoh K, Furukawa G, Kitade K, Katsumata N, Kobayashi Y, Obara Y. Postprandial changes in plasma GH and insulin concentrations, and responses to stimulation with GH-releasing hormone (GHRH) and GHRP-6 in calves around weaning. J Endocrinol. 2004;183:497–505
  8. Le Quellec A, Kervran A, Blache P, Ciurana AJ, Bataille D. Oxyntomodulin-like immunoreactivity: Diurnal profile of a new potential enterogastrone. J Clin Endocrinol Metab. 1992;74:1405–1409
  9. Bataille D, Tatemoto K, Gespach C, Jornvall H, Rosselin G, Mutt V. Isolation of glucagon-37 (bioactive enteroglucagon/oxyntomodulin) from porcine jejuno-ileum (Characterization of the peptide). FEBS Lett. 1982;146:79–86
  10. Holst JJ. Evidence that enteroglucagon (II) is identical with the C-terminal sequence (residue 33–69) of glicentin. Biochem J. 1982;207:381–388
  11. Dakin CL, Small CJ, Batterham RL, Neary NM, Cohen MA, Patterson M, et al. Peripheral oxyntomodulin reduces food intake and body weight gain in rats. Endocrinology. 2004;145:2687–2695
  12. Cohen MA, Ellis SM, Le Roux CW, Batterham RL, Park A, Patterson M, et al. Oxyntomodulin suppresses appetite and reduces food intake in humans. J Clin Endocrinol Metab. 2003;88:4696–4701
  13. Jarrousse C, Bataillle D, Jeanrenaud B. A Pure enteroglucagon, oxyntomodulin (glucagon 37), stimulates insulin release in perfused rat pancreas. Endocrinology. 1984;115:102–105
  14. Holst JJ. Interaction of hepatocytes membrane receptors with pancreatic and gut glucagon. In:  Foa PP,  Baja JS,  Foa NL editor. Glucagon: Its Role in Physiology and Clinical Medicine. New York, NY: Springer; 1977;p. 287–303
  15. Tai HH, Korsch B, Chey WY. Preparation of 125I-labeled secretin of high specific radioactivity. Anal Biochem. 1975;69:34–42
  16. Harada E, Kanno T. Progressive enhancement in the secretory functions of the digestive system of the rat in the course of cold acclimation. J Physiol. 1976;260:620–645
  17. English PJ, Ghatei MA, Malik IA, Bloom SR, Wilding JP. Food fails to suppress ghrelin levels in obese humans. J Clin Endocrinol Metab. 2002;87:2984–2987
  18. Callahan HS, Cummings DE, Pepe MS, Breen PA, Matthys CC, Weigle DS. Postprandial suppression of plasma ghrelin level is proportional to ingested caloric load but does not predict intermeal interval in humans. J Clin Endocrinol Metab. 2004;89:1319–1324
  19. Baldissera FGA, Holst JJ, Knuhtesn S, Hilsted L, Nielsen OV. Oxyntomodulin (glicentin-[33-69]): pharmacokinetics, binding to liver cell membranes, effects on isolated perfused pig pancreas, and secretion from isolated perfused lower small intestine of pigs. Regul Pept. 1988;21:151–166
  20. Bataille D, Coudray AM, Carlqvist M, Rosselin G, Mutt V. Isolation of glucagon-37 (bioactive enteroglucagon/oxyntomodulin) from porcine jejuno-ileum (Isolation of the peptide). FEBS Lett. 1982;146:73–78
  21. Holst JJ. Evidence that enteroglucagon (II) is identical with the C-terminal sequence (residue 33–69) of glicentin. Biochem J. 1982;207:381–388

PII: S0739-7240(10)00042-1

doi: 10.1016/j.domaniend.2010.05.001

Domestic Animal Endocrinology
Volume 39, Issue 3 , Pages 163-170 , October 2010

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