Domestic Animal Endocrinology
Volume 39, Issue 4 , Pages 215-221 , November 2010

Effect of recombinant human TSH on the uptake of radioactive iodine (123I) by the thyroid gland in healthy beagles

  • M. Campos

      Affiliations

    • Department of Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine – Ghent University, Merelbeke, Belgium
    • Corresponding Author InformationCorresponding author. Tel.: +32 9 264 77 00; fax: +32 9 265 77 91
  • ,
  • K. Peremans

      Affiliations

    • Department of Veterinary Medical Imaging and Small Animal Orthopaedics, Faculty of Veterinary Medicine – Ghent University, Merelbeke, Belgium
  • ,
  • L. Duchateau

      Affiliations

    • Department of Physiology and Biometrics, Faculty of Veterinary Medicine – Ghent University, Merelbeke, Belgium
  • ,
  • A. Dobbeleir

      Affiliations

    • Department of Veterinary Medical Imaging and Small Animal Orthopaedics, Faculty of Veterinary Medicine – Ghent University, Merelbeke, Belgium
  • ,
  • E. Vandermeulen

      Affiliations

    • Department of Veterinary Medical Imaging and Small Animal Orthopaedics, Faculty of Veterinary Medicine – Ghent University, Merelbeke, Belgium
  • ,
  • I. van Hoek

      Affiliations

    • Department of Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine – Ghent University, Merelbeke, Belgium
  • ,
  • G. Paes

      Affiliations

    • Department of Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine – Ghent University, Merelbeke, Belgium
  • ,
  • S. Daminet

      Affiliations

    • Department of Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine – Ghent University, Merelbeke, Belgium

References 

  1. Worth AJ, Zuber RM, Hocking M. Radioiodide (131I) therapy for the treatment of canine thyroid carcinoma. Aust Vet J. 2005;83:208–214
  2. Harari J, Patterson JS, Rosenthal RC. Clinical and pathologic features of thyroid tumors in 26 dogs. J Am Vet Med Assoc. 1986;188:1160–1164
  3. Turrel JM, McEntee MC, Burke BP, Page RL. Sodium iodide I 131 treatment of dogs with nonresectable thyroid tumors: 39 cases (1990-2003). J Am Vet Med Assoc. 2006;229:542–548
  4. Berg G, Lindstedt G, Suurkula M, Jansson S. Radioiodine ablation and therapy in differentiated thyroid cancer under stimulation with recombinant human thyroid-stimulating hormone. J Endocrinol Invest. 2002;25:44–52
  5. Woodmansee WW, Haugen BR. A review of the potential uses for recombinant human TSH in patients with thyroid cancer and nodular goiter. Clin Endocrinol (Oxf). 2004;61:163–173
  6. Nielsen VE, Bonnema SJ, Jorgensen HB, Grupe P, Hegedius L. Stimulation with 0,3 mg recombinant human thyrotropin (rhTSH) increases the effect of 131I therapy in patients with nontoxic nodular goiter (A prospective, randomized, double-blind trial–secondary publication). [in Danish] Ugeskr Laeger. 2006;168:4098–4101
  7. Pena S, Arum S, Cross M, Magnani B, Pearce EN, Oates ME, et al. 123I thyroid uptake and thyroid size at 24, 48, and 72 hours after the administration of recombinant human thyroid-stimulating hormone to normal volunteers. J Clin Endocrinol Metab. 2006;91:506–510
  8. Cubas ER, Paz-Filho GJ, Olandoski M, Goedert CA, Woellner LC, Carvalho GA, et al. Recombinant human TSH increases the efficacy of a fixed activity of radioiodine for treatment of multinodular goitre. Int J Clin Pract. 2008;63:583–590
  9. Luster M, Lippi F, Jarzab B, Perros P, Lassmann M, Reiners C, et al. rhTSH-aided radioiodine ablation and treatment of differentiated thyroid carcinoma: a comprehensive review. Endocr Relat Cancer. 2005;12:49–64
  10. Nieuwlaat WA, Huysmans DA, van den Bosch HC, Sweep CG, Ross HA, Corstens FH, et al. Pretreatment with a single, low dose of recombinant human thyrotropin allows dose reduction of radioiodine therapy in patients with nodular goiter. J Clin Endocrinol Metab. 2003;88:3121–3129
  11. Nieuwlaat WA, Hermus AR, Ross HA, Buijs WC, Edelbroek MA, Bus JW, et al. Dosimetry of radioiodine therapy in patients with nodular goiter after pretreatment with a single, low dose of recombinant human thyroid-stimulating hormone. J Nucl Med. 2004;45:626–633
  12. Pacini F, Ladenson PW, Schlumberger M, Driedger A, Luster M, Kloos RT, et al. Radioiodine ablation of thyroid remnants after preparation with recombinant human thyrotropin in differentiated thyroid carcinoma: results of an international, randomized, controlled study. J Clin Endocrinol Metab. 2006;91:926–932
  13. Boretti FS, Sieber-Ruckstuhl NS, Favrot C, Lutz H, Hofmann-Lehmann R, Reusch CE. Evaluation of recombinant human thyroid-stimulating hormone to test thyroid function in dogs suspected of having hypothyroidism. Am J Vet Res. 2006;67:2012–2016
  14. Daminet S, Jeusette I, Duchateau L, Diez M, Van de Maele I, De Rick A. Evaluation of thyroid function in obese dogs and in dogs undergoing a weight loss protocol. J Vet Med A Physiol Pathol Clin Med. 2003;50:213–218
  15. Daminet S, Fifle L, Paradis M, Duchateau L, Moreau M. Use of recombinant human thyroid-stimulating hormone for thyrotropin stimulation test in healthy, hypothyroid and euthyroid sick dogs. Can Vet J. 2007;48:1273–1279
  16. van Hoek I, Daminet S, Vandermeulen E, Dobbeleir A, Duchateau L, Peremans K. Recombinant human thyrotropin administration enhances thyroid uptake of radioactive iodine in hyperthyroid cats. J Vet Intern Med. 2008;22:1340–1344
  17. Braverman LE, Pratt BM, Ebner S, Longcope C. Recombinant human thyrotropin stimulates thyroid function and radioactive iodine uptake in the rhesus monkey. J Clin Endocrinol Metab. 1992;74:1135–1139
  18. Park HM, Perkins OW, Edmondson JW, Schnute RB, Manatunga A. Influence of diagnostic radioiodines on the uptake of ablative dose of iodine-131. Thyroid. 1994;4:49–54
  19. Park HM, Park YH, Zhou XH. Detection of thyroid remnant/metastasis without stunning: an ongoing dilemma. Thyroid. 1997;7:277–280
  20. Panakova L, Koch H, Kolb S, Mueller RS. Thyroid testing in Sloughis. J Vet Intern Med. 2008;22:1144–1148
  21. De Roover K, Duchateau L, Carmichael N, van Geffen C, Daminet S. Effect of storage of reconstituted recombinant human thyroid-stimulating hormone (rhTSH) on thyroid-stimulating hormone (TSH) response testing in euthyroid dogs. J Vet Intern Med. 2006;20:812–817
  22. Pinilla M, Shiel RE, Brennan SF, McAllister H, Mooney CT. Quantitative Thyroid Scintigraphy in Greyhounds Suspected of Primary Hypothyroidism. Vet Radiol Ultrasound. 2009;50:224–229
  23. Torres MS, Ramirez L, Simkin PH, Braverman LE, Emerson CH. Effect of various doses of recombinant human thyrotropin on the thyroid radioactive iodine uptake and serum levels of thyroid hormones and thyroglobulin in normal subjects. J Clin Endocrinol Metab. 2001;86:1660–1664
  24. Huysmans DA, Nieuwlaat WA, Erdtsieck RJ, Schellekens AP, Bus JW, Bravenboer B, et al. Administration of a single low dose of recombinant human thyrotropin significantly enhances thyroid radioiodide uptake in nontoxic nodular goiter. J Clin Endocrinol Metab. 2000;85:3592–3596
  25. Kogai T, Endo T, Saito T, Miyazaki A, Kawaguchi A, Onaya T. Regulation by thyroid-stimulating hormone of sodium/iodide symporter gene expression and protein levels in FRTL-5 cells. Endocrinology. 1997;138:2227–2232
  26. Weiss SJ, Philp NJ, Ambesi-Impiombato FS, Grollman EF. Thyrotropin-stimulated iodide transport mediated by adenosine 3′,5′-monophosphate and dependent on protein synthesis. Endocrinology. 1984;114:1099–1107
  27. Woolfenden JM. Thyroid stunning revisited. J Nucl Med. 2006;47:1403–1405
  28. Sisson JC, Avram AM, Lawson SA, Gauger PG, Doherty GM. The so-called stunning of thyroid tissue. J Nucl Med. 2006;47:1406–1412
  29. Medvedec M. Thyroid stunning. J Nucl Med. 2001;42:1129–1131
  30. Kalinyak JE, McDougall IR. Whole-body scanning with radionuclides of iodine, and the controversy of “thyroid stunning.”. Nucl Med Commun. 2004;25:883–889
  31. Hilditch TE, Dempsey MF, Bolster AA, McMenemin RM, Reed NS. Self-stunning in thyroid ablation: evidence from comparative studies of diagnostic 131I and 123I. Eur J Nucl Med Mol Imaging. 2002;29:783–788
  32. Cohen JB, Kalinyak JE, McDougall IR. Clinical implications of the differences between diagnostic 123I and post-therapy 131I scans. Nucl Med Commun. 2004;25:129–134
  33. Childs DS, Keating FR, Rall JE, Williams MM, Power MH. The effect of varying quantities of inorganic iodide (carrier) on the urinary excretion and thyroidal accumulation of radioiodine in exophthalmic goiter. J Clin Invest. 1950;29:726–738
  34. Sauvé F, Paradis M. Use of recombinant human thyroid-stimulating hormone for thyrotropin stimulation test in euthyroid dogs. Can Vet J. 2000;41:215–219

PII: S0739-7240(10)00063-9

doi: 10.1016/j.domaniend.2010.05.003

Domestic Animal Endocrinology
Volume 39, Issue 4 , Pages 215-221 , November 2010