Domestic Animal Endocrinology
Volume 42, Issue 2 , Pages 83-93 , February 2012

Age-related changes in gene expression of the growth hormone secretagogue and growth hormone-releasing hormone receptors in Holstein-Friesian cattle

  • M. Komatsu

      Affiliations

    • National Institute of Livestock and Grassland Science, Ikenodai 2, Tsukuba, Ibaraki 305-0901, Japan
    • Corresponding Author InformationCorresponding author at: Animal Breeding and Reproduction Research Team, National Institute of Livestock and Grassland Science, 2 Ikenodai, Tsukuba, Ibaraki, 305-0901, Japan. Tel.: +81 29 838 8640; fax: +81 29 838 8623
    • ,
  • M. Kojima

      Affiliations

    • National Institute of Agrobiological Sciences, Ikenodai 2, Tsukuba, Ibaraki 305-0901, Japan
    • ,
  • H. Okamura

      Affiliations

    • National Institute of Agrobiological Sciences, Ikenodai 2, Tsukuba, Ibaraki 305-0901, Japan
    • ,
  • M. Nishio

      Affiliations

    • National Institute of Livestock and Grassland Science, Ikenodai 2, Tsukuba, Ibaraki 305-0901, Japan
    • ,
  • M. Kaneda

      Affiliations

    • National Institute of Livestock and Grassland Science, Ikenodai 2, Tsukuba, Ibaraki 305-0901, Japan
    • ,
  • T. Kojima

      Affiliations

    • National Agricultural Research Centre for Western Region, Oda, Shimane 694-0013, Japan
    • ,
  • H. Takeda

      Affiliations

    • National Institute of Livestock and Grassland Science, Ikenodai 2, Tsukuba, Ibaraki 305-0901, Japan
    • ,
  • A.E.O. Malau-Aduli

      Affiliations

    • School of Agricultural Science/TIAR, University of Tasmania, Hobart, Tasmania, Australia
    • ,
  • H. Takahashi

      Affiliations

    • National Institute of Livestock and Grassland Science, Ikenodai 2, Tsukuba, Ibaraki 305-0901, Japan

Received 16 April 2011 ,Revised 23 September 2011 ,Accepted 26 September 2011.

References 

  1. Lin-Su K , Wajnrajch MP . Growth hormone releasing hormone (GHRH) and the GHRH receptor . Rev Endocr Metab Disord . 2002;3:313–323
  2. Anderson LL, Jeftinija S, Scanes CG, Stromer MH, Lee JS, Jeftinija K, et al. Physiology of ghrelin and related peptides . Domest Anim Endocrinol . 2005;29:111–144
  3. Kojima M , Kangawa K . Ghrelin: structure and function . Physiol Rev . 2005;85:495–522
  4. Leshin LS , Barb CR , Kiser TE , Rampacek GB , Kraeling RR . Growth hormone-releasing hormone and somatostatin neurons within the porcine and bovine hypothalamus . Neuroendocrinology . 1994;59:251–264
  5. Cruz CR , Smith RG . The growth hormone secretagogue receptor . Vitam Horm . 2008;77:47–88
  6. Mano-Otagiri A, Nemoto T, Sekino A, Yamauchi N, Shuto Y, Sugihara H, et al. Growth hormone-releasing hormone (GHRH) neurons in the arcuate nucleus (Arc) of the hypothalamus are decreased in transgenic rats whose expression of ghrelin receptor is attenuated: Evidence that ghrelin receptor is involved in the up-regulation of GHRH expression in the Arc . Endocrinology . 2006;147:4093–4103
  7. Leung PK, Chow KB, Lau PN, Chu KM, Chan CB, Cheng CH, et al. The truncated ghrelin receptor polypeptide (GHS-R1b) acts as a dominant-negative mutant of the ghrelin receptor . Cell Signal . 2007;19:1011–1022
  8. Purchas RW , Macmillan KL , Hafs HD . Pituitary and plasma growth hormone levels in bulls from birth to one year of age . J Anim Sci . 1970;31:358–363
  9. McAndrews JM , Stroud CM , MacDonald RD , Hymer WC , Deaver DR . Age-related changes in the secretion of growth hormone in vivo and in vitro in infantile and prepubertal Holstein bull calves . J Endocrinol . 1993;139:307–315
  10. Baumgard LH, Weber WJ, Kazmer GW, Zinn SA, Hansen LB, Chester-Jones H, et al. Effects of selection for milk yield on growth hormone response to growth hormone releasing factor in growing Holstein calves . J Dairy Sci . 2002;85:2529–2540
  11. Weber WJ, Baumgard LH, Kazmer GW, Zinn SA, Hansen LB, Chester-Jones H, et al. Growth hormone response to growth hormone releasing hormone in calves that differ in genetic merit for milk yield . J Dairy Sci . 2005;88:1723–1731
  12. Itoh F, Komatsu T, Yonai M, Sugino T, Kojima M, Kangawa K, et al. GH secretory responses to ghrelin and GHRH in growing and lactating dairy cattle . Domest Anim Endocrinol . 2005;28:34–45
  13. Katoh K , Furukawa G , Kitade K , Katsumata N , Kobayashi Y , Obara Y . Postprandial changes in plasma GH and insulin concentrations, and responses to stimulation with GH-releasing hormone (GHRH) and GHRP-6 in calves around weaning . J Endocrinol . 2004;183:497–505
  14. ThidarMyint H , Yoshida H , Ito T , He M , Inoue H , Kuwayama H . Combined administration of ghrelin and GHRH synergistically stimulates GH release in Holstein preweaning calves . Domest Anim Endocrinol . 2008;34:118–123
  15. Vernon RG , Sasaki S . Control of responsiveness of tissues to hormones . In:  Tsuda T ,  Sasaki Y ,  Kawashima R editor. Physiological Aspects of Digestion and Metabolism in Ruminants . San Diego, CA: Academic Press; 1991;p. 155–182
  16. Kamegai J , Wakabayashi I , Kineman RD , Frohman LA . Growth hormone-releasing hormone receptor (GHRH-R) and growth hormone secretagogue receptor (GHS-R) mRNA levels during postnatal development in male and female rats . J Neuroendocrinol . 1997;11:299–306
  17. Sun Y , Garcia JM , Smith RG . Ghrelin and growth hormone secretagogue receptor expression in mice during aging . Endocrinology . 2007;148:1323–1329
  18. Gnanapavan S, Kola B, Bustin SA, Morris DG, McGee P, Fairclough P, et al. The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans . J Clin Endocrinol Metab . 2002;87:2988–2991
  19. Connor EE , Ashwell MS , Dahl GE . Characterization and expression of the bovine growth hormone-releasing hormone (GHRH) receptor . Domest Anim Endocrinol . 2002;22:189–200
  20. Komatsu M, Fujimori Y, Sato Y, Okamura H, Sasaki S, Itoh T, et al. Nucleotide polymorphisms and the 5′-UTR transcriptional analysis of the bovine growth hormone secretagogue receptor 1a (GHSR1a) gene . Anim Sci J . 2010;81:530–550
  21. Komatsu M, Itoh T, Fujimori Y, Satoh M, Miyazaki Y, Takahashi H, et al. Genetic association between GHSR1a 5'UTR-microsatellite and nt-7(C>A) loci and growth and carcass traits in Japanese Black cattle . Anim Sci J . 2011;82:396–405
  22. Bennett PA, Thomas GB, Howard AD, Feighner SD, Van der Ploeg LH, Smith RG, et al. Hypothalamic growth hormone secretagogue-receptor (GHS-R) expression is regulated by growth hormone in the rat . Endocrinology . 1997;138:4552–4557
  23. SAS Institute . Statistical Analysis, Release 9:2 . Cary, NC: SAS Institute Inc.; 2002;
  24. Argente J , Chowen JA , Zeitler P , Clifton DK , Steiner RA . Sexual dimorphism of growth hormone-releasing hormone and somatostatin gene expression in the hypothalamus of the rat during development . Endocrinology . 1991;128:2369–2375
  25. Guilloteau P , Le Huërou-Luron I , Chayvialle JA , Toullec R , Zabielski R , Blum JW . Gut regulatory peptides in young cattle and sheep . Vet Med . 1997;A44:1–23
  26. Cunha SR , Mayo KE . Ghrelin and growth hormone (GH) secretagogues potentiate GH-releasing hormone (GHRH)-induced cyclic adenosine 3′,5′-monophosphate production in cells expressing transfected GHRH and GH secretagogue receptors . Endocrinology . 2002;143:4570–4582
  27. Casanueva FF , Camiña JP , Carreira MC , Pazos Y , Varga JL , Schally AV . Growth hormone-releasing hormone as an agonist of the ghrelin receptor GHS-R1a . Proc Natl Acad Sci U S A . 2008;105:20452–20457
  28. Holst B , Brandt E , Bach A , Heding A , Schwartz TW . Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrelin signaling . Mol Endocrinol . 2005;19:2400–2411
  29. Relling AE , Pate JL , Reynolds CK , Loerch SC . Effect of feed restriction and supplemental dietary fat on gut peptide and hypothalamic neuropeptide messenger ribonucleic acid concentrations in growing wethers . J Anim Sci . 2010;88:737–748
  30. Hodgeson J . The development of food intake in calves, 4: The effect of the addition of material to the rumen, or its removal from the rumen, on voluntary food intake . Anim Prod . 1971;13:581–592
  31. Forbes JM . Effects of physiological state and animal productivity . In:  Forbes JM editors. The Voluntary Food Intake of Farm Animals . London, UK: Butterworths Ltd; 1986;p. 67–85
  32. Block SS, Smith JM, Ehrhardt RA, Diaz MC, Rhoads RP, Van Amburgh ME, et al. Nutritional and developmental regulation of plasma leptin in dairy cattle . J Dairy Sci . 2003;86:3206–3214
  33. McLaughlin CL . Role of peptides from gastrointestinal cells in food intake regulation . J Anim Sci . 1982;55:1515–1527
  34. Murata M, Okimura Y, Iida K, Matsumoto M, Sowa H, Kaji H, et al. Ghrelin modulates the downstream molecules of insulin signaling in hepatoma cells . J Biol Chem . 2002;277:5667–5674
  35. Dixit VD, Schaffer EM, Pyle RS, Collins GD, Sakthivel SK, Palaniappan R, et al. Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells . J Clin Invest . 2004;114:57–66
  36. Inoue H, Ogawa W, Ozaki M, Haga S, Matsumoto M, Furukawa K, et al. Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo . Nat Med . 2004;10:168–174
  37. Leat WMF . Carbohydrate and lipid metabolism in the ruminant during post-natal development . In:  Phillipson AT editors. Digestive Physiology and Metabolism in the Ruminants . Newcastle upon Tyne, England: Oriel Press; 1970;p. 211–222
  38. Date Y , Nakazato M , Kangawa K , Matsuo H . Gastro-entero-pancreatic actions of ghrelin . In:  Ghigo E editors. Ghrelin . Norwell, MA: Kluwer Academic Publishers; 2004;p. 179–193
  39. Desbois C, Clerc P, Le Huërou-Luron I, Le Dréan G, Gestin M, Dufresne M, et al. Differential tissular expression of the CCK(A) and CCK(B) gastrin receptor genes during postnatal development in the calf . Life Sci . 1998;63:2059–2070
  40. Lundell I, Blomqvist AG, Berglund MM, Schober DA, Johnson D, Statnick MA, et al. Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY . J Biol Chem . 1995;270:29123–29128
  41. Havt A, Schally AV, Halmos G, Varga JL, Toller GL, Horvath JE, et al. The expression of the pituitary growth hormone-releasing hormone receptor and its splice variants in normal and neoplastic human tissues . Proc Natl Acad Sci U S A . 2005;102:17424–17429
  42. Oliveira CR, Salvatori R, Nóbrega LM, Carvalho EO, Menezes M, Farias CT, et al. Sizes of abdominal organs in adults with severe short stature due to severe, untreated, congenital GH deficiency caused by a homozygous mutation in the GHRH receptor gene . Clin Endocrinol (Oxf) . 2008;69:153–158

PII: S0739-7240(11)00147-0

doi: 10.1016/j.domaniend.2011.09.006

Domestic Animal Endocrinology
Volume 42, Issue 2 , Pages 83-93 , February 2012

Article Tools

* Image Usage & Resolution